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Induction of NFATC1 degradation in human MINO cells at 100 nM measured after 8 hrs by proteomic analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of NFATC activity in human CD4+ T cells assessed as reduction of IL-2 secretion preincubated for 2 hrs followed by anti-CD3/CD28 stimulation and measured after 48 hrs by ELISA
Assay data:3 Active, 3 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of NFATC activity in human CD4+ T cells assessed as reduction of IFN gamma secretion preincubated for 2 hrs followed by anti-CD3/CD28 stimulation and measured after 48 hrs by ELISA
Inhibition of NFATC activity in human PBMC cells assessed as reduction of IFN gamma gene expression preincubated for 2 hrs followed by ionomycin/phorbol 12-myristate 13-acetate stimulation and measured after 4 hrs byRT-PCR analysis
Assay data:3 Tested
Inhibition of NFATC activity in human PBMC cells assessed as reduction of IL2 gene expression preincubated for 2 hrs followed by ionomycin/phorbol 12-myristate 13-acetate stimulation and measured after 4 hrs by RT-PCR analysis
Inhibition of NFATC activity in HEK293T cells preincubated for 2 hrs followed by ionomycin/phorbol 12-myristate 13-acetate stimulation and measured after 4 hrs by luciferase reporter assay
Assay data:1 Active, 7 Tested
Inhibition of NFATC activity in HEK293T cells at 50 uM preincubated for 2 hrs followed by ionomycin/phorbol 12-myristate 13-acetate stimulation and measured after 4 hrs by luciferase reporter assay
Assay data:10 Tested
Inhibition of NFATC activity in HEK293T cells at 5 to 50 uM preincubated for 2 hrs followed by ionomycin/phorbol 12-myristate 13-acetate stimulation and measured after 4 hrs by luciferase reporter assay
Assay data:11 Tested
Inhibition of human NFAT-1 in human Jurkat cells assessed as decrease of PMA/ionomycin-induced IL-2 concentration at 15 uM measured after 44 hrs by western blot assay
Assay data:1 Active, 1 Tested
Inhibition of human NFAT-1 in human Jurkat cells assessed as decrease of PMA/ionomycin-induced IL-2 concentration measured after 44 hrs by western blot assay
Inhibition of human NFAT-1 in human Jurkat cells assessed as decrease of PMA/ionomycin-induced NFAT dephosphorylation measured after 44 hrs by western blot assay
Inhibition of human NFAT-1 in human Jurkat cells assessed as decrease of PMA/ionomycin-induced NFAT dephosphorylation at 15 uM measured after 44 hrs by western blot assay
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Induction of nuclear translocation of human GFP-tagged NFATc1 expressed in virus infected primary human skeletal muscle myoblasts after 3 hrs by DAPI staining based assay
Assay data:11 Active, 1 Activity ≤ 1 µM, 33 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Reduction in NFATc1 nuclear localization in human anti-CD3/anti-CD28 stimulated Jurkat T cells at 10 ug measured after 15 mins by SDS-PAGE and immunoblot analysis
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
InfectX: Pathogen infection siRNA screens
Assay data:115372 Tested
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