BioAssay by Target (List) for Gene (Select 471) - PubChem BioAssay - NCBI

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Select item 3212661.

Inhibition of human aminoimidazole carboxamide transformylase

Source:: ChEMBL

Protein Target:: Bifunctional purine biosynthesis protein ATIC

Assay data:1 Tested

AID:: 321266

Summary PubMed Citation Related BioAssays by Target

Select item 2379922.

Average inhibition of AICAR formyltransferase at 25 uM and 50 uM concentration relative to cappsin 2 (X); 0.3X

Source:: ChEMBL

Protein Target:: Bifunctional purine biosynthesis protein ATIC

Assay data:1 Tested

AID:: 237992

Summary PubMed Citation Related BioAssays by Target

Select item 2379933.

Average inhibition of AICAR formyltransferase at 25 uM and 50 uM concentration relative to cappsin 2 (X); 0.4X

Source:: ChEMBL

Protein Target:: Bifunctional purine biosynthesis protein ATIC

Assay data:1 Tested

AID:: 237993

Summary PubMed Citation Related BioAssays by Target

Select item 2379944.

Average inhibition of AICAR formyltransferase at 25 uM and 50 uM concentration relative to cappsin 2 (X); 0.5X

Source:: ChEMBL

Protein Target:: Bifunctional purine biosynthesis protein ATIC

Assay data:1 Tested

AID:: 237994

Summary PubMed Citation Related BioAssays by Target

Select item 2379955.

Average inhibition of AICAR formyltransferase at 25 uM and 50 uM concentration relative to cappsin 2 (X); 0.6X

Source:: ChEMBL

Protein Target:: Bifunctional purine biosynthesis protein ATIC

Assay data:1 Tested

AID:: 237995

Summary PubMed Citation Related BioAssays by Target

Select item 2379966.

Average inhibition of AICAR formyltransferase at 25 uM and 50 uM concentration relative to cappsin 2 (X); 0.8X

Source:: ChEMBL

Protein Target:: Bifunctional purine biosynthesis protein ATIC

Assay data:4 Tested

AID:: 237996

Summary PubMed Citation Related BioAssays by Target

Select item 2379977.

Average inhibition of AICAR formyltransferase at 25 uM and 50 uM concentration relative to cappsin 2 (X); 0.9X

Source:: ChEMBL

Protein Target:: Bifunctional purine biosynthesis protein ATIC

Assay data:2 Tested

AID:: 237997

Summary PubMed Citation Related BioAssays by Target

Select item 2379988.

Average inhibition of AICAR formyltransferase at 25 uM and 50 uM concentration relative to cappsin 2 (X); 1.1X

Source:: ChEMBL

Protein Target:: Bifunctional purine biosynthesis protein ATIC

Assay data:1 Tested

AID:: 237998

Summary PubMed Citation Related BioAssays by Target

Select item 2379999.

Average inhibition of AICAR formyltransferase at 25 uM and 50 uM concentration relative to cappsin 2 (X); 1.2X

Source:: ChEMBL

Protein Target:: Bifunctional purine biosynthesis protein ATIC

Assay data:1 Tested

AID:: 237999

Summary PubMed Citation Related BioAssays by Target

Select item 23800010.

Average inhibition of AICAR formyltransferase at 25 uM and 50 uM concentration relative to cappsin 2; Inactive

Source:: ChEMBL

Protein Target:: Bifunctional purine biosynthesis protein ATIC

Assay data:10 Tested

AID:: 238000

Summary PubMed Citation Related BioAssays by Target

Select item 23800111.

Average inhibition of AICAR formyltransferase at 25 uM and 50 uM concentration relative to cappsin 2 (X); (0.7X)

Source:: ChEMBL

Protein Target:: Bifunctional purine biosynthesis protein ATIC

Assay data:1 Tested

AID:: 238001

Summary PubMed Citation Related BioAssays by Target

Select item 23819312.

Inhibition constant against AICAR formyltransferase

Source:: ChEMBL

Protein Target:: Bifunctional purine biosynthesis protein ATIC

Assay data:2 Active, 2 Tested

AID:: 238193

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 26457013.

Inhibition of human recombinant AICAR Tfase

Source:: ChEMBL

Protein Target:: Bifunctional purine biosynthesis protein ATIC

Assay data:5 Tested

AID:: 264570

Summary PubMed Citation Related BioAssays by Target

Select item 28234414.

Inhibition of human AICAR Tfase

Source:: ChEMBL

Protein Target:: Bifunctional purine biosynthesis protein ATIC

Assay data:7 Active, 1 Activity ≤ 1 µM, 24 Tested

AID:: 282344

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 23799115.

Average inhibition of AICAR formyltransferase at 25 uM and 50 uM concentration relative to cappsin 2 (X); 0.2X

Source:: ChEMBL

Protein Target:: Bifunctional purine biosynthesis protein ATIC

Assay data:2 Tested

AID:: 237991

Summary PubMed Citation Related BioAssays by Target

Select item 36048216.

Inhibition of IMPCH activity of human wild-type ATIC

Source:: ChEMBL

Protein Target:: Bifunctional purine biosynthesis protein ATIC

Assay data:4 Active, 4 Activity ≤ 1 µM, 5 Tested

AID:: 360482

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 36048517.

Inhibition of human recombinant AICAR transformylase

Source:: ChEMBL

Protein Target:: Bifunctional purine biosynthesis protein ATIC

Assay data:4 Tested

AID:: 360485

Summary PubMed Citation Related BioAssays by Target

Select item 36048618.

Activity of human wild-type ATIC assessed as IMPCH activity

Source:: ChEMBL

Protein Target:: Bifunctional purine biosynthesis protein ATIC

Assay data:1 Active, 1 Tested

AID:: 360486

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 36307219.

Inhibition of human recombinant AICAR transformylase

Source:: ChEMBL

Protein Target:: Bifunctional purine biosynthesis protein ATIC

Assay data:10 Tested

AID:: 363072

Summary PubMed Citation Related BioAssays by Target

Select item 62409920.

An siRNA screen for human genes that are involved in human papilloma virus (HPV) E2 transcriptional repression of the E6 and E7 oncogenes

Source:: ICCB-Longwood Screening Facility, Harvard Medical School

Assay data:497 Active, 21019 Tested

AID:: 624099

Summary PubMed Citation

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Target

RNAi Target, Active (5)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (34)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (1)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (17)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (39)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (8)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (99)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (12)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (1)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (99)
BioAssays extracted from the literature
NIH MLP (1)
BioAssays deposited by the NIH Molecular Libraries Program
Other (11)
BioAssays deposited by other experimentalists

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