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Binding affinity to human NPSR by radioligand binding assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
PRESTO-Tango GPCRome screening (NPS)
Assay data:1 Tested
SummaryRelated BioAssays by Target
Antagonist activity at human Gq-coupled NPSR1b expressed in human U2OS cells assessed as inhibition in neuropeptide S-induced beta-arrestin 2 recruitment incubated for 30 mins followed by neuropeptide S addition and measured after 90 or 180 mins by pathhunter beta-arrestin assay
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Antagonist activity at human Gq-coupled NPSR1b expressed in human U2OS cells assessed as inhibition in neuropeptide S-induced beta-arrestin 2 recruitment at 20 uM incubated for 30 mins followed by neuropeptide S addition and measured after 90 or 180 mins by pathhunter beta-arrestin assay relative to control
Assay data:9 Tested
SummaryPubMed CitationRelated BioAssays by Target
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Human NPS receptor (Neuropeptide S receptor)
Assay data:9 Active, 9 Tested
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
InfectX: Pathogen infection siRNA screens
Assay data:115372 Tested
A whole genome RNAi screen highlights components of the ER/Golgi as a prominent source of resistance to immunotoxin-mediated cytotoxicity
Assay data:555 Active, 64752 Tested
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
Assay data:8 Active, 7 Activity ≤ 1 µM, 8 Tested
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assay
Assay data:3 Active, 1 Activity ≤ 1 µM, 3 Tested
Displacement of [125I]Tyr10-NPS from neuropeptide S receptor (unknown origin)
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
Assay data:21 Active, 16 Activity ≤ 1 µM, 33 Tested
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
Assay data:26 Active, 3 Activity ≤ 1 nM, 22 Activity ≤ 1 µM, 33 Tested
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assay
Assay data:11 Active, 1 Activity ≤ 1 nM, 11 Activity ≤ 1 µM, 11 Tested
Displacement of [125I]Tyr10-NPS from human neuropeptide S receptor expressed in CHO cells after 1.5 hrs by liquid scintillation counting
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation at 50 uM after 20 mins by HTRF assay relative to control
Assay data:11 Tested
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