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Inhibition of HSET in human MDA-MB-231 cells overexpressing HSET and possessing supernumerary centrosomes assessed as inhibition of centrosome clustering by measuring increase in multipolar spindle formation incubated for 24 hrs by Hoechst 33342 staining based fluorescence microscopic method
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of HSET in human MDA-MB-231 cells overexpressing HSET and possessing supernumerary centrosomes assessed as inhibition of centrosome clustering by measuring increase in multipolar spindle formation at 250 uM incubated for 24 hrs by Hoechst 33342 staining based fluorescence microscopic method
Assay data:2 Tested
Inhibition of HSET in human MDA-MB-231 cells overexpressing HSET and possessing supernumerary centrosomes assessed as inhibition of centrosome clustering by measuring increase in multipolar spindle formation at 40 uM incubated for 24 hrs by Hoechst 33342 staining based fluorescence microscopic method relative to control
Inhibition of HSET in human MDA-MB-231 cells overexpressing HSET and possessing supernumerary centrosomes assessed as inhibition of centrosome clustering by measuring increase in multipolar spindle formation at 20 uM incubated for 24 hrs by Hoechst 33342 staining based fluorescence microscopic method relative to control
Inhibition of HSET in human MDA-MB-231 cells overexpressing HSET and possessing supernumerary centrosomes assessed as inhibition of centrosome clustering by measuring bipolar spindle formation at 40 uM incubated for 24 hrs by Hoechst 33342 staining based fluorescence microscopic method relative to control
Inhibition of HSET in human MDA-MB-231 cells overexpressing HSET and possessing supernumerary centrosomes assessed as inhibition of centrosome clustering by measuring bipolar spindle formation at 20 uM incubated for 24 hrs by Hoechst 33342 staining based fluorescence microscopic method relative to control
Inhibition of recombinant His6-tagged HSET (unknown origin) assessed as reduction in Alexa-594 labelled microtubule gliding at 30 uM measured every 2 secs for 20 secs by epifluorescence microscopic analysis relative to control
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
Inhibition of KIFC1 in human BT549 cells assessed as induction of multipolar spindle formation at 0.4 uM after 44 hrs
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of KIFC1 in human HeLa cells assessed as induction of multipolar spindle formation at 0.4 uM after 44 hrs
Inhibition of KIFC1 in human HeLa cells assessed as reversal of monospindle phenotype
Inhibition of recombinant N-terminal His6-tagged KIFC1 (Q305-K673 aa) (unknown origin) expressed in Escherichia coli BL21 (DE3) by malachite green assay
Assay data:22 Active, 11 Activity ≤ 1 µM, 37 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
InfectX: Pathogen infection siRNA screens
Assay data:115372 Tested
A whole genome RNAi screen highlights components of the ER/Golgi as a prominent source of resistance to immunotoxin-mediated cytotoxicity
Assay data:555 Active, 64752 Tested
RNAi screen for vorinostat resistance genes - Primary Screen
Assay data:450 Active, 18118 Tested
Druggable Genome siRNA Screen for Enhancers of Camptothecin in MDA-MB-231 Breast Cancer Cells
Assay data:167 Active, 26449 Tested
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