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Cross screening panel
Assay data:1 Tested
SummaryRelated BioAssays by Target
Safety47 Scan (DiscoverX - Eurofins)
Inhibition of Kv7.1 channel (unknown origin) upto 10000 nM
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of KCNQ1/MINK (unknown origin) at 10 uM
Inhibition of recombinant human KCNQ1
Assay data:4 Tested
Inhibition of human KCNQ1 at 10 uM relative to control by Electrophysiological QPatch assay
Agonist activity at human KCNQ1 channel expressed in CHO cells assessed as amplitude change of outward current at 10 uM by patch clamp method
Agonist activity at human KCNQ1 channel expressed in CHO cells assessed as amplitude change of outward current at 0.1 uM by patch clamp method
Agonist activity at human KCNQ1 channel expressed in CHO cells assessed as shift of half voltage of maximal activation at 10 uM by patch clamp method
Agonist activity at human KCNQ1 channel expressed in CHO cells assessed as shift of half voltage of maximal activation at 0.1 uM by patch clamp method
Inhibition of KCNQ1/MINK (unknown origin) by patch clamp method
Agonist activity at human KCNQ1 channel expressed in CHO cells assessed as increase in outward current by patch clamp electrophysiology method
Effect on human Kv7.1 expressed in Xenopus laevis oocytes at 10 uM at holding potential of -90 mV by patch clamp electrophysiology
KvLQT1/minK Eurofins SafetyScreen (Other)
Inhibition of human KCNQ1 at 10 uM
Inhibition of human KCNQ1 at 30 uM comprehensive in-vitro proarrhythmia assay
K+V channel CEREP ligand profiling
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