BioAssay by Target (List) for Gene (Select 3760) - PubChem BioAssay - NCBI

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Select item 19520091.

Inhibition of GIRK1/2 (unknown origin) channel

Source:: ChEMBL

Protein Targets:: G protein-activated inward rectifier potassium channel 1; ...
Total:: 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1952009

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19519942.

Inhibition of recombinant human GIRK1/2 channel

Source:: ChEMBL

Protein Targets:: G protein-activated inward rectifier potassium channel 1; ...
Total:: 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested

AID:: 1951994

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19519933.

Inhibition of recombinant human GIRK1/4 channel

Source:: ChEMBL

Protein Targets:: G protein-activated inward rectifier potassium channel 1; ...
Total:: 2

Assay data:17 Active, 17 Activity ≤ 1 µM, 18 Tested

AID:: 1951993

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19191234.

IonWorks Quattro system from US Patent US11530213: "Naphthyridinone derivatives and their use in the treatment of arrhythmia"

Source:: BindingDB

Protein Targets:: G protein-activated inward rectifier potassium channel 1; ...
Total:: 2

Assay data:93 Active, 89 Activity ≤ 1 µM, 93 Tested

AID:: 1919123

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 18657225.

Activation of GIRK1/4 channel (unknown origin) expressed in HEK293 cells assessed as efficacy incubated for 6 mins by thallium flux assay relative to VU0466551

Source:: ChEMBL

Protein Targets:: G protein-activated inward rectifier potassium channel 1; ...
Total:: 2

Assay data:40 Tested

AID:: 1865722

Summary PubMed Citation Related BioAssays by Target

Select item 18657216.

Activation of GIRK1/4 channel (unknown origin) expressed in HEK293 cells incubated for 6 mins by thallium flux assay

Source:: ChEMBL

Protein Targets:: G protein-activated inward rectifier potassium channel 1; ...
Total:: 2

Assay data:23 Active, 12 Activity ≤ 1 µM, 42 Tested

AID:: 1865721

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 18657207.

Activation of GIRK1/2 channel (unknown origin) expressed in HEK293 cells assessed as efficacy incubated for 6 mins by thallium flux assay relative to VU0466551

Source:: ChEMBL

Protein Targets:: G protein-activated inward rectifier potassium channel 1; ...
Total:: 2

Assay data:40 Tested

AID:: 1865720

Summary PubMed Citation Related BioAssays by Target

Select item 18657198.

Activation of GIRK1/2 channel (unknown origin) expressed in HEK293 cells incubated for 6 mins by thallium flux assay

Source:: ChEMBL

Protein Targets:: G protein-activated inward rectifier potassium channel 1; ...
Total:: 2

Assay data:31 Active, 22 Activity ≤ 1 µM, 42 Tested

AID:: 1865719

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 16692189.

Inhibition of human GIRK1 at 100 uM

Source:: ChEMBL

Protein Target:: G protein-activated inward rectifier potassium channel 1

Assay data:2 Tested

AID:: 1669218

Summary PubMed Citation Related BioAssays by Target

Select item 162483910.

Activation of human GIRK1/4 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay relative to control

Source:: ChEMBL

Protein Targets:: G protein-activated inward rectifier potassium channel 1; ...
Total:: 2

Assay data:55 Tested

AID:: 1624839

Summary PubMed Citation Related BioAssays by Target

Select item 162483811.

Activation of human GIRK1/4 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay

Source:: ChEMBL

Protein Targets:: G protein-activated inward rectifier potassium channel 1; ...
Total:: 2

Assay data:36 Active, 21 Activity ≤ 1 µM, 55 Tested

AID:: 1624838

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 162483712.

Activation of human GIRK1/2 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay relative to control

Source:: ChEMBL

Protein Targets:: G protein-activated inward rectifier potassium channel 1; ...
Total:: 2

Assay data:55 Tested

AID:: 1624837

Summary PubMed Citation Related BioAssays by Target

Select item 162483613.

Activation of human GIRK1/2 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay

Source:: ChEMBL

Protein Targets:: G protein-activated inward rectifier potassium channel 1; ...
Total:: 2

Assay data:40 Active, 32 Activity ≤ 1 µM, 56 Tested

AID:: 1624836

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 159416314.

Inhibition of Kir3.1 (unknown origin)

Source:: ChEMBL

Protein Target:: G protein-activated inward rectifier potassium channel 1

Assay data:1 Active, 1 Tested

AID:: 1594163

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 152545815.

Inhibition GIRK1/4 (unknown origin)

Source:: ChEMBL

Protein Targets:: G protein-activated inward rectifier potassium channel 1; ...
Total:: 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1525458

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 150858816.

RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen

Source:: Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre

Assay data:790 Active, 18119 Tested

AID:: 1508588

Select item 142358217.

Inhibition of GIRK-1/4 channel (unknown origin) expressed in HEK293 cells by automated patch clamp method

Source:: ChEMBL

Protein Targets:: G protein-activated inward rectifier potassium channel 1; ...
Total:: 2

Assay data:6 Active, 7 Tested

AID:: 1423582

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 142358118.

Inhibition of GIRK-1/4 channel (unknown origin) expressed in HEK293 cells at 10 uM by automated patch clamp method relative to control

Source:: ChEMBL

Protein Targets:: G protein-activated inward rectifier potassium channel 1; ...
Total:: 2

Assay data:16 Tested

AID:: 1423581

Summary PubMed Citation Related BioAssays by Target

Select item 142358019.

Inhibition of GIRK-1/4 channel (unknown origin) expressed in HEK293 cells at 1 uM by automated patch clamp method relative to control

Source:: ChEMBL

Protein Targets:: G protein-activated inward rectifier potassium channel 1; ...
Total:: 2

Assay data:17 Tested

AID:: 1423580

Summary PubMed Citation Related BioAssays by Target

Select item 136788920.

Inhibition of human Kir3.1/3.4 at 10 uM by patch clamp method relative to control

Source:: ChEMBL

Protein Targets:: G protein-activated inward rectifier potassium channel 1; ...
Total:: 2

Assay data:1 Tested

AID:: 1367889

Summary PubMed Citation Related BioAssays by Target

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Target

Proteins (9)
BioAssays with protein sequences specified as targets
RNAi Target, Active (6)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Chemical Probes (2)
BioAssays with compounds reported as validated chemical probes

Active Compounds (34)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 µM (25)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (2)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (34)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (9)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (62)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (13)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (9)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (53)
BioAssays extracted from the literature
NIH MLP (9)
BioAssays deposited by the NIH Molecular Libraries Program
Other (13)
BioAssays deposited by other experimentalists

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