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Inhibition of GIRK1/2 (unknown origin) channel
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of recombinant human GIRK1/2 channel
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
Inhibition of recombinant human GIRK1/4 channel
Assay data:17 Active, 17 Activity ≤ 1 µM, 18 Tested
IonWorks Quattro system from US Patent US11530213: "Naphthyridinone derivatives and their use in the treatment of arrhythmia"
Assay data:93 Active, 89 Activity ≤ 1 µM, 93 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Activation of GIRK1/4 channel (unknown origin) expressed in HEK293 cells assessed as efficacy incubated for 6 mins by thallium flux assay relative to VU0466551
Assay data:40 Tested
SummaryPubMed CitationRelated BioAssays by Target
Activation of GIRK1/4 channel (unknown origin) expressed in HEK293 cells incubated for 6 mins by thallium flux assay
Assay data:23 Active, 12 Activity ≤ 1 µM, 42 Tested
Activation of GIRK1/2 channel (unknown origin) expressed in HEK293 cells assessed as efficacy incubated for 6 mins by thallium flux assay relative to VU0466551
Activation of GIRK1/2 channel (unknown origin) expressed in HEK293 cells incubated for 6 mins by thallium flux assay
Assay data:31 Active, 22 Activity ≤ 1 µM, 42 Tested
Inhibition of human GIRK1 at 100 uM
Assay data:2 Tested
Activation of human GIRK1/4 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay relative to control
Assay data:55 Tested
Activation of human GIRK1/4 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay
Assay data:36 Active, 21 Activity ≤ 1 µM, 55 Tested
Activation of human GIRK1/2 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay relative to control
Activation of human GIRK1/2 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay
Assay data:40 Active, 32 Activity ≤ 1 µM, 56 Tested
Inhibition of Kir3.1 (unknown origin)
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition GIRK1/4 (unknown origin)
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Inhibition of GIRK-1/4 channel (unknown origin) expressed in HEK293 cells by automated patch clamp method
Assay data:6 Active, 7 Tested
Inhibition of GIRK-1/4 channel (unknown origin) expressed in HEK293 cells at 10 uM by automated patch clamp method relative to control
Assay data:16 Tested
Inhibition of GIRK-1/4 channel (unknown origin) expressed in HEK293 cells at 1 uM by automated patch clamp method relative to control
Assay data:17 Tested
Inhibition of human Kir3.1/3.4 at 10 uM by patch clamp method relative to control
Assay data:1 Tested
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