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Inhibition of IL-6Ralpha/GP130 interaction in ER-negative human SUM159 cells overexpressing IL-6 assessed as inhibition of constitutive STAT3 phosphorylation at Y705 at 10 to 30 uM after 24 hrs by Western blot analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
Summary
InfectX: Pathogen infection siRNA screens
Assay data:115372 Tested
SummaryPubMed Citation
A whole genome RNAi screen highlights components of the ER/Golgi as a prominent source of resistance to immunotoxin-mediated cytotoxicity
Assay data:555 Active, 64752 Tested
Inhibition of IL-6Ralpha/GP130 interaction in human PANC-1 cells assessed as inhibition of IL-6-induced STAT3 phosphorylation at Y705 at 25 uM preincubated for 30 mins followed by IL-6 induction measured after 24 hrs by Western blot analysis
Binding affinity to GP130 in human RH30 cells assessed as protection against pronase-induced cleavage at 100 to 1000 uM preincubated for 1 hr followed by pronase induction measured after 30 mins by DARTS assay
Assay data:2 Active, 2 Tested
Inhibition of IL-6Ralpha/GP130 interaction in ER-negative human SUM159 cells overexpressing IL-6 assessed as inhibition of constitutive STAT3 phosphorylation at Y705 at 15 to 50 uM after 24 hrs by Western blot analysis
Inhibition of IL-6Ralpha/GP130 interaction in human PANC-1 cells assessed as inhibition of IL-6-induced STAT3 phosphorylation at Y705 preincubated for 30 mins followed by IL-6 induction measured after 24 hrs by Western blot analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of LIFR/GP130 interaction in human PANC-1 cells assessed as inhibition of LIF-induced STAT3 phosphorylation at Y705 at 25 uM after 24 hrs by Western blot analysis
Assay data:2 Tested
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
Binding affinity to GP130 (unknown origin) by surface plasmon resonance analysis
RNAi screen for vorinostat resistance genes - Primary Screen
Assay data:450 Active, 18118 Tested
Druggable Genome siRNA Screen for Enhancers of Camptothecin in MDA-MB-231 Breast Cancer Cells
Assay data:167 Active, 26449 Tested
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Ambion Library)
Assay data:9227 Active, 64752 Tested
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Dharmacon Library)
Assay data:826 Active, 18119 Tested
An siRNA screen for human genes that are involved in human papilloma virus (HPV) E2 transcriptional repression of the E6 and E7 oncogenes
Assay data:497 Active, 21019 Tested
siRNA Circadian Assay
Assay data:527 Active, 33364 Tested
SummaryPubMed CitationRelated BioAssays by Depositor
Binding affinity to immobilized GP130 (unknown origin) by SPR analysis
Assay data:1 Active, 2 Tested
Inhibition of GP130 in human A549 cells assessed as reduction in cyclin-D1 protein expression after 24 hrs by Western blot analysis
Inhibition of GP130 in human A549 cells assessed as reduction in bcl2 protein expression after 24 hrs by Western blot analysis
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