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Viability secondary screen, Ras selective lethality- DRD cells Measured in Cell-Based System Using Plate Reader - 2013-08_Inhibitor_Dose_DryPowder_Activity_Set4
Assay data:14 Active, 4 Activity ≤ 1 µM, 15 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
In vitro for inhibition of nucleotide exchange process of oncogenic Ras
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of nucleotide exchange process of oncogenic Ras in vitro
Assay data:10 Active, 1 Activity ≤ 1 µM, 20 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of nucleotide exchange process of oncogenic Ras at concentration 50 uM
Assay data:19 Tested
SummaryRelated BioAssays by Target
Inhibition of human recombinant p21RAS by GDPX assay
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to H-Ras(1-166) expressed in BL21 De3 Escherichia coli by isothermal titration calorimetric study
Assay data:1 Tested
Binding affinity to hexa-histidine tagged H-Ras.GDP(1-166) expressed in BL21 De3 Escherichia coli by NMR binding experiment
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to H-Ras expressed in BL21 De3 Escherichia coli assessed as induction of protein denaturation by circular dichroism
Binding affinity to H-Ras expressed in BL21 De3 Escherichia coli assessed as damage to protein structure by circular dichroism
Viability counterscreen, Ras selective lethality- BJeHLT cells Measured in Cell-Based System Using Plate Reader - 2013-07_Inhibitor_Dose_DryPowder_Activity_Set4
Assay data:13 Active, 1 Activity ≤ 1 µM, 15 Tested
Inhibitory [3H]GDP concentration against oncogenic Ha-ras protein (p21 Leu-61)
Assay data:15 Tested
Viability counterscreen, Ras selective lethality- BJeH cells Measured in Cell-Based System Using Plate Reader - 2013-06_Inhibitor_Dose_DryPowder_Activity_Set4
Assay data:9 Active, 15 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
SAR compounds for Cdc42 probe extension project tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically H-Ras activated mutant, round 1
Assay data:1 Active, 1 Activity ≤ 1 µM, 5 Tested
SAR compounds for Cdc42 probe extension project tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras wildtype, round 1
SAR compounds tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically H-Ras activated mutant, round 1
Assay data:11 Active, 11 Activity ≤ 1 µM, 27 Tested
SAR compounds tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically H-Ras wildtype, round 1
Dose Response of round 1 SAR compounds for Cdc42 probe extension project tested by multiplex of eight GTPase proteins under the condition of Mg Buffer, non-chelator buffer
Assay data:5 Active, 5 Tested
Dose Response of round 1 SAR compounds for GTPase inhibitor project tested by multiplex of eight GTPase proteins under the condition of Mg Buffer, non-chelator buffer
Assay data:11 Active, 26 Tested
SAR compounds tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically H-Ras activated mutant, round 2
Assay data:22 Active, 21 Activity ≤ 1 µM, 25 Tested
SAR compounds tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically H-Ras wildtype, round 2
Assay data:23 Active, 20 Activity ≤ 1 µM, 25 Tested
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