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Activation of human sGC assessed as increase in intracellular cGMP level in presence of DETA-NO and Tween-20
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Activation of human sGC assessed as increase in intracellular cGMP level in presence of DETA-NO and ODQ
Activation of human sGC assessed as increase in intracellular cGMP level in presence of DETA-NO
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Activation of sGC (unknown origin) in presence of DETA-NO by Glosensor cGMP assay
Assay data:27 Active, 22 Activity ≤ 1 µM, 27 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of soluble guanylate cyclase (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Activation of sGC (unknown origin) assessed as cGMP formation using GTP as substrate by Catch-point cGMP assay relative to DMSO
Assay data:24 Tested
SummaryRelated BioAssays by Target
Activation of SGC in HEK293 cells assessed as cGMP production at 30 uM after 20 mins by LC-MS/MS analysis in presence of NO-donor DETA-NONOate
Assay data:13 Tested
Activation of SGC in HEK293 cells assessed as cGMP production after 20 mins by LC-MS/MS analysis in presence of NO-donor DETA-NONOate
Assay data:19 Active, 17 Activity ≤ 1 µM, 33 Tested
Binding affinity to full length human recombinant sGC by surface plasmon resonance analysis
Inhibition of sGC (unknown origin) assessed as inhibition of cGMP production in presence of 20 nM sGC activator cinaciguat
Inhibition of sGC (unknown origin) assessed as inhibition of cGMP production in presence of 1 uM sGC activator cinaciguat
Binding affinity to human recombinant sGC catalytic subunit by surface plasmon resonance analysis
Assay data:17 Tested
Activation of sGC in human hCMEC/D3 cells assessed as production of cGMP per million cells using [3H]-cGMP after 1 hr by liquid scintillation counting
Assay data:9 Tested
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
Activation of soluble guanylate cyclase (unknown origin) assessed as apparent initial rate of oxidation of oxyhemoglobin
SummaryCompounds, ActiveRelated BioAssays by Target
Activation of soluble guanylate cyclase (unknown origin) assessed as apparent initial rate of oxidation of oxyhemoglobin in presence of cysteine relative to GTN
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