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Inhibition of TGFbeta1 receptor in TGFbeta1-stimulated Sprague-Dawley rat cardiac fibroblasts assessed as reduction in alpha-SMA expression at 2 mM measured after 12 hrs by Western blot analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of TGFbeta1 receptor in TGFbeta1-stimulated Sprague-Dawley rat cardiac fibroblasts assessed as reduction in fibronectin expression at 50 uM measured after 12 hrs by Western blot analysis
Assay data:20 Active, 31 Tested
Inhibition of TGFbeta1 receptor in TGFbeta1-stimulated Sprague-Dawley rat cardiac fibroblasts assessed as reduction in fibronectin expression at 10 uM measured after 12 hrs by Western blot analysis relative to control
Assay data:19 Active, 31 Tested
Inhibition of TGFbeta1 receptor in TGFbeta1-stimulated Sprague-Dawley rat cardiac fibroblasts assessed as reduction in fibronectin expression measured after 12 hrs by Western blot analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of TGFbeta1 receptor in TGFbeta1-stimulated Sprague-Dawley rat cardiac fibroblasts assessed as reduction in alpha-SMA expression measured after 12 hrs by Western blot analysis
Inhibition of TGFbeta1 receptor in TGFbeta1-stimulated Sprague-Dawley rat cardiac fibroblasts assessed as reduction in collagen 1 expression measured after 12 hrs by Western blot analysis
Inhibition of TGFbeta1 receptor in TGFbeta1-stimulated Sprague-Dawley rat cardiac fibroblasts assessed as reduction in collagen 3 expression measured after 12 hrs by Western blot analysis
Inhibition of TGFbeta1 receptor in TGFbeta1-stimulated Sprague-Dawley rat cardiac fibroblasts assessed as reduction in fibronectin mRNA expression at 2.5 to 10 uM measured after 12 hrs by qRT-PCR analysis
Inhibition of TGFbeta1 receptor in TGFbeta1-stimulated Sprague-Dawley rat cardiac fibroblasts assessed as reduction in alpha-SMA mRNA expression at 2.5 to 10 uM measured after 12 hrs by qRT-PCR analysis
Inhibition of TGFbeta1 receptor in TGFbeta1-stimulated Sprague-Dawley rat cardiac fibroblasts assessed as reduction in collagen 1 mRNA expression at 2.5 to 10 uM measured after 12 hrs by qRT-PCR analysis
Inhibition of TGFbeta1 receptor in TGFbeta1-stimulated Sprague-Dawley rat cardiac fibroblasts assessed as reduction in collagen 3 mRNA expression at 2.5 to 10 uM measured after 12 hrs by qRT-PCR analysis
Inhibition of TGFbeta1 receptor in TGFbeta1-stimulated Sprague-Dawley rat cardiac fibroblasts assessed as reduction in Smad3 phosphorylation at 10 uM measured after 5 to 30 mins by Western blot analysis
Inhibition of TGFbeta1 receptor in TGFbeta1-stimulated Sprague-Dawley rat cardiac fibroblasts assessed as reduction in Smad2 phosphorylation at 10 uM measured after 5 to 30 mins by Western blot analysis
Inhibition of TGFbeta1 receptor in TGFbeta1-stimulated Sprague-Dawley rat cardiac fibroblasts assessed as reduction in fibronectin expression at 2 mM measured after 12 hrs by Western blot analysis
Inhibition of TGFbeta1 receptor in TGFbeta1-stimulated Sprague-Dawley rat cardiac fibroblasts assessed as reduction in Smad3 nuclear translocation at 10 uM measured after 5 mins by DAPI staining-based laser confocal microscopic analysis
Inhibition of TGFbeta1 receptor in TGFbeta1-stimulated Sprague-Dawley rat cardiac fibroblasts assessed as reduction in collagen 1 expression at 2 mM measured after 12 hrs by Western blot analysis
Inhibition of TGFbeta1 receptor in TGFbeta1-stimulated Sprague-Dawley rat cardiac fibroblasts assessed as reduction in collagen 3 expression at 2 mM measured after 12 hrs by Western blot analysis
Inhibition of TGFbeta1 receptor in TGFbeta1-stimulated Sprague-Dawley rat cardiac fibroblasts assessed as reduction in fibronectin expression at 20 uM measured after 12 hrs by Western blot analysis
Inhibition of TGFbeta1 receptor in TGFbeta1-stimulated Sprague-Dawley rat cardiac fibroblasts assessed as reduction in alpha-SMA expression at 20 uM measured after 12 hrs by Western blot analysis
Inhibition of TGFbeta1 receptor in TGFbeta1-stimulated Sprague-Dawley rat cardiac fibroblasts assessed as reduction in collagen 1 expression at 20 uM measured after 12 hrs by Western blot analysis
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