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DNA Polymerase Assay from Article 10.1016/j.bmc.2009.08.051: "Synthesis and structure-activity relationships of dehydroaltenusin derivatives as selective DNA polymerase alpha inhibitors."
Assay data:6 Active, 6 Activity ≤ 1 µM, 10 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to rat DNA polymerase beta with homo-lysine modification at 72 assessed as inhibition of dRP excision in presence of 32P-end labelled duplex DNA at 10 uM by SDS PAGE
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to rat DNA polymerase beta with methyl-lysine modification at 72 assessed as inhibition of dRP excision in presence of 32P-end labelled duplex DNA at 10 uM by SDS PAGE
Binding affinity to wild type rat DNA polymerase beta assessed as inhibition of dRP excision in presence of 32P-end labelled duplex DNA at 10 uM by SDS PAGE analysis
Binding affinity to rat DNA polymerase beta with homo-lysine modification at 72 assessed as inhibition of dRP excision in presence of 32P-end labelled duplex DNA at 25 uM by SDS PAGE
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to rat DNA polymerase beta with methyl-lysine modification at 72 assessed as inhibition of dRP excision in presence of 32P-end labelled duplex DNA at 25 uM by SDS PAGE
Binding affinity to wild type rat DNA polymerase beta assessed as inhibition of dRP excision in presence of 32P-end labelled duplex DNA at 50 uM by SDS PAGE analysis
Assay data:3 Active, 4 Tested
Binding affinity to rat DNA polymerase beta with methyl-lysine modification at 72 assessed as inhibition of dRP excision in presence of 32P-end labelled duplex DNA at 50 uM by SDS PAGE
Binding affinity to rat DNA polymerase beta with homo-lysine modification at 72 assessed as inhibition of dRP excision in presence of 32P-end labelled duplex DNA at 50 uM by SDS PAGE
Assay data:2 Active, 4 Tested
Binding affinity to wild type rat DNA polymerase beta assessed as inhibition of dRP excision in presence of 32P-end labelled duplex DNA at 25 uM by SDS PAGE analysis
Inhibition of rat recombinant DNA polymerase beta expressed in Escherichia coli JMpbeta5 cells assessed as incorporation of [3H]dTTP into poly(dA)/oligo(dT)18 DNA-template primer at 100 uM after 60 mins
Assay data:6 Active, 6 Tested
Inhibition of rat recombinant DNA polymerase beta expressed in Escherichia coli JMpbeta5 cells assessed as incorporation of [3H]dTTP into poly(dA)/oligo(dT)18 DNA-template primer after 60 mins
Assay data:1 Active, 8 Tested
Inhibition of recombinant rat DNA polymerase beta expressed in Escherichia coli JMpbeta5 assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 after 60 mins
Assay data:4 Tested
Competitive inhibition of recombinant rat DNA polymerase beta using poly(dA)/oligo(dT)18 as substrate by Lineweaver-Burk plot analysis
Noncompetitive inhibition of recombinant rat DNA polymerase beta using dTTP as substrate by Lineweaver-Burk plot analysis
Inhibition of rat DNA polymerase beta using poly(dA)/oligo(dT)18 (A/T, 2/1)/dTTP DNA template-primer substrate measured at 37 degC for 60 mins
Inhibition of rat DNA polymerase beta expressed in Escherichia coli JMpbeta5 assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 after 60 mins
Assay data:3 Tested
Inhibition of rat pol beta using poly(dA)/oligo(dT)18 (A/T = 2/1) and dTTP as the DNA template-primer and nucleotide substrate after 60 mins
Assay data:1 Active, 2 Tested
Inhibition of rat DNA polymerase beta by [3H]dTTP incorporation assay
Assay data:10 Tested
Inhibition of rat DNA polymerase beta assessed as incorporation of [3H]dTTP
Assay data:5 Tested
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