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Negative allosteric modulation of mGlu7 (unknown origin) in cells expressing G protein-regulated inwardly rectifying potassium channels (GIRKs) assessed as inhibition of L-AP4-induced response measured by thallium flux assay relative to control
Assay data:22 Tested
SummaryPubMed CitationRelated BioAssays by Target
Negative allosteric modulation of mGlu7 (unknown origin) in cells expressing G protein-regulated inwardly rectifying potassium channels (GIRKs) assessed as inhibition of L-AP4-induced response measured by thallium flux assay
Assay data:15 Active, 4 Activity ≤ 1 µM, 16 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
In Vitro Pharmacology from US Patent US11414395: "Heterocyclic compounds as modulators of mGluR7"
Assay data:120 Active, 120 Activity ≤ 1 µM, 136 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
PRESTO-Tango GPCRome screening (GRM7)
Assay data:1 Tested
SummaryRelated BioAssays by Target
Binding affinity to mGlu7 (unknown origin)
Positive allosteric modulation of human mGluR7 in presence of EC20 concentration of L-AP4 by calcium mobilization assay relative to L-AP4
Assay data:11 Tested
Positive allosteric modulation of human mGluR7 in presence of EC20 concentration of L-AP4 by calcium mobilization assay
Assay data:11 Active, 10 Activity ≤ 1 µM, 12 Tested
Positive allosteric modulation of human mGlu7 receptor
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Agonist activity at human mGlu7 receptor
Antagonist activity at mGluR7 (unknown origin) by FLIPR assay
Inhibition of mGluR7 (unknown origin)
Negative allosteric modulator activity at human mGlu7 assessed as reduction in Ca2+ mobilization by HTS assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Agonist activity at human mGlu7
Agonist activity at mGlu7 (unknown origin)
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
Agonist activity at human mGlu7 expressed in CHO cells assessed as reduction in forskolin-induced cAMP production
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Allosteric agonist activity at human mGlu7 expressed in CHO cells assessed as reduction in forskolin-induced cAMP production after 30 mins by cAMP reagent-based assay relative to control
Assay data:5 Tested
Allosteric agonist activity at human mGlu7 expressed in CHO cells assessed as reduction in forskolin-induced cAMP production after 30 mins by cAMP reagent-based assay
Assay data:5 Active, 3 Activity ≤ 1 µM, 5 Tested
Negative allosteric modulation of mGlu7R (unknown origin)
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Antagonist activity at recombinant human mGlu7 receptor expressed in hamster AV12 cells co-expressing rat EAAT1/Galpha15 assessed as inhibition of glutamate induced increase in Ca2+ flux after 2.5 mins by Fluo-3 AM dye-based FLIPR assay
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