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Selectivity interaction (Kinase panel (Millipore, radiometric filter-binding assay, conc. ATP = Km)) EUB0000613a TBK1
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Affinity Biochemical interaction (TR-FRET-based kinase activity inhibition assay (1 M ATP)) EUB0000701a TBK1
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Affinity Biochemical interaction (TR-FRET-based kinase activity inhibition assay (1 M ATP)) EUB0000305b TBK1
Affinity On-target Cellular interaction (NanoBRET assay (HEK293T cells)) EUB0000701a TBK1
Assay data:1 Tested
SummaryRelated BioAssays by Target
Affinity On-target Cellular interaction (NanoBRET assay (HEK293T cells)) EUB0000305b TBK1
Affinity Phenotypic Cellular interaction (pIRF3 cell-based mechanistic assay in MDA-MB231 cells) EUB0000305b TBK1
Inhibition of TBK1 (unknown origin) at 50 nM by Z'LYTE screening method relative to control
Assay data:3 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human TBK1
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of TBK1 (unknown origin) at 1.0 uM relative to control
Inhibition of TBK1 (unknown origin) at 1 uM relative to control
Inhibition of TBK1 (unknown origin)
Inhibition of TBK1 (unknown origin) at 0.5 uM relative to control
TBK1 DiscoveRx kinase panel
TBK1(h) Kinase panel
Inhibition of TBK1 (unknown origin) at 1 uM
Inhibition of wild-type human full length TBK1 (M1 to L729 residues) expressed in mammalian expression system at 10 uM by Kinomescan method relative to control
Assay data:2 Tested
Inhibition of human TTBK1 (1 to 479 residues) using Casein as substrate measured after 40 mins in presence of [gamma33P]ATP by scintillation counting method
Assay data:8 Active, 7 Activity ≤ 1 µM, 8 Tested
Inhibition of wild-type human full length TBK1 (M1 to L729 residues) expressed in mammalian expression system at 1 uM by Kinomescan method relative to control
Displacement of tracer K5 from NLuc fused TBK1 (unknown origin) expressed in HEK293 cells by NanoBRET assay
Assay data:9 Active, 3 Activity ≤ 1 µM, 22 Tested
Inhibition of human recombinant TBK1 assessed as reduction in substrate phosphorylation at 50 to 500 nM using ATP and Ulight-CKKSRGDYMTMQIG (IRS-1) incubated for 60 min by LANCE detection method
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