BioAssay by Target (List) for Gene (Select 29028) - PubChem BioAssay - NCBI

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Select item 13751461.

Binding affinity to human partial length DNA-tagged ATAD2A expressed in bacterial by BROMOscan method

Source:: ChEMBL

Protein Target:: ATPase family AAA domain-containing protein 2

Assay data:1 Tested

AID:: 1375146

Summary PubMed Citation Related BioAssays by Target

Select item 12343792.

Binding affinity to FLAG-6His-Tev-ATAD2 (950 to 1148) (unknown origin) expressed in Escherichia coli BL21 (DE3) by SPR analysis

Source:: ChEMBL

Protein Target:: ATPase family AAA domain-containing protein 2

Assay data:7 Active, 5 Activity ≤ 1 µM, 7 Tested

AID:: 1234379

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 12343803.

Binding affinity to ATAD2 (unknown origin) by BROMOscan panel based assay

Source:: ChEMBL

Protein Target:: ATPase family AAA domain-containing protein 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1234380

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 12343894.

Binding affinity to ATAD2 in human HUT78 cells incubated for 45 mins by mass spectrometry based bromosphere chemoproteomic assay

Source:: ChEMBL

Protein Target:: ATPase family AAA domain-containing protein 2

Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested

AID:: 1234389

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 12344125.

Binding affinity to ATAD2(unknown origin) by peptide FRET assay

Source:: ChEMBL

Protein Target:: ATPase family AAA domain-containing protein 2

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1234412

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 12486726.

Binding affinity to recombinant human ATAD2 (982 to 1108 amino acids) bromodomain radiolabelled at methyl groups of leucine, valine, isoleucine, methionine expressed in Escherichia coli BL21 (DE3) by NMR titration

Source:: ChEMBL

Protein Target:: ATPase family AAA domain-containing protein 2

Assay data:7 Tested

AID:: 1248672

Summary Related BioAssays by Target

Select item 12704287.

Binding affinity to recombinant human his-tagged ATAD2 expressed in Escherichia coli BL21(DE3) cells by isothermal titration calorimetry

Source:: ChEMBL

Protein Target:: ATPase family AAA domain-containing protein 2

Assay data:1 Tested

AID:: 1270428

Summary Related BioAssays by Target

Select item 12797668.

Binding affinity to biotinylated ATAD2 (unknown origin) expressed in Escherichia coli at 0.2 to 1 uM by Biolayer Interferometric analysis

Source:: ChEMBL

Protein Target:: ATPase family AAA domain-containing protein 2

Assay data:2 Tested

AID:: 1279766

Summary PubMed Citation Related BioAssays by Target

Select item 12821559.

Inhibition of recombinant human ATAD2A expressed in bacterial system assessed as residual activity at 1 uM by bromoscan assay relative to control

Source:: ChEMBL

Protein Target:: ATPase family AAA domain-containing protein 2

Assay data:1 Tested

AID:: 1282155

Summary PubMed Citation Related BioAssays by Target

Select item 128253310.

Inhibition of GST-tagged human ATAD2 using H4KAc 5/8/12/16 peptide as substrate incubated overnight by HTRF assay

Source:: ChEMBL

Protein Target:: ATPase family AAA domain-containing protein 2

Assay data:1 Tested

AID:: 1282533

Summary PubMed Citation Related BioAssays by Target

Select item 134607611.

Human ATPase family, AAA domain containing 2 (3.6.1.3 ATPases)

Source:: IUPHAR/BPS Guide to PHARMACOLOGY

Protein Target:: ATPase family AAA domain-containing protein 2

Assay data:4 Active, 4 Tested

AID:: 1346076

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 135377112.

Inhibition of biotinylated-H4KAc4 binding to human His6-tagged ATAD2 expressed in Escherichia coli BL21(DE3) at 50 uM after 2.5 hrs by luminescence-based AlphaScreen assay relative to control

Source:: ChEMBL

Protein Target:: ATPase family AAA domain-containing protein 2

Assay data:14 Tested

AID:: 1353771

Summary PubMed Citation Related BioAssays by Target

Select item 135612813.

Binding affinity to human ATAD2A (Q981 to R1108 residues) expressed in bacterial expression system by BROMOScan assay

Source:: ChEMBL

Protein Target:: ATPase family AAA domain-containing protein 2

Assay data:1 Tested

AID:: 1356128

Summary PubMed Citation Related BioAssays by Target

Select item 137128114.

Binding affinity to human partial length ATAD2A (Q981 to R1108 residues) expressed in bacterial expression system by BROMOscan assay

Source:: ChEMBL

Protein Target:: ATPase family AAA domain-containing protein 2

Assay data:1 Tested

AID:: 1371281

Summary PubMed Citation Related BioAssays by Target

Select item 137223815.

Binding affinity to human partial length ATAD2A (Q981 to R1108 residues) expressed in bacterial expression system by BROMOscan assay

Source:: ChEMBL

Protein Target:: ATPase family AAA domain-containing protein 2

Assay data:1 Tested

AID:: 1372238

Summary PubMed Citation Related BioAssays by Target

Select item 123437716.

Binding affinity to ATAD2 (unknown origin) using HuT-78 chromatin lysate incubated for 2 hrs by bromosphere competition binding assay

Source:: ChEMBL

Protein Target:: ATPase family AAA domain-containing protein 2

Assay data:16 Active, 14 Activity ≤ 1 µM, 16 Tested

AID:: 1234377

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 137514717.

Binding affinity to human partial length DNA-tagged ATAD2B expressed in bacterial by BROMOscan method

Source:: ChEMBL

Protein Target:: ATPase family AAA domain-containing protein 2

Assay data:1 Tested

AID:: 1375147

Summary PubMed Citation Related BioAssays by Target

Select item 137612618.

Binding affinity to ATAD2 (unknown origin) by isothermal titration calorimetry

Source:: ChEMBL

Protein Target:: ATPase family AAA domain-containing protein 2

Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested

AID:: 1376126

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 137612719.

Binding affinity to partial length human ATAD2A (Q981 to R1108) expressed in bacterial expression system by Bromoscan method

Source:: ChEMBL

Protein Target:: ATPase family AAA domain-containing protein 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1376127

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 137612820.

Displacement of fluorescently labelled histone H3.3 from truncated Nluc-ATAD2 (unknown origin) by cell-based NanoBRET assay

Source:: ChEMBL

Protein Target:: ATPase family AAA domain-containing protein 2

Assay data:1 Active, 1 Tested

AID:: 1376128

Summary Compounds, Active PubMed Citation Related BioAssays by Target

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Target

Proteins (1)
BioAssays with protein sequences specified as targets
RNAi Target, Active (7)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (37)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (1)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (28)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (70)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (10)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (102)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (14)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (1)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (91)
BioAssays extracted from the literature
NIH MLP (1)
BioAssays deposited by the NIH Molecular Libraries Program
Other (24)
BioAssays deposited by other experimentalists

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BioAssay by Target (List) for Gene (Select 29028) (116)
PubChem BioAssay
PREDICTED: Homo sapiens ATPase family AAA domain containing 2 (ATAD2), transcrip...
PREDICTED: Homo sapiens ATPase family AAA domain containing 2 (ATAD2), transcript variant X3, mRNA
gi|2217371800|ref|XM_047421723.1|

Nucleotide
ATPase family AAA domain-containing protein 2 isoform X2 [Homo sapiens]
ATPase family AAA domain-containing protein 2 isoform X2 [Homo sapiens]
gi|2462619172|ref|XP_054216340.1|

Protein
RecName: Full=ATPase family AAA domain-containing protein 2; AltName: Full=AAA n...
RecName: Full=ATPase family AAA domain-containing protein 2; AltName: Full=AAA nuclear coregulator cancer-associated protein; Short=ANCCA
gi|74762365|sp|Q6PL18.1|ATAD2_HUMAN

Protein
G0S2 G0/G1 switch 2 [Homo sapiens]
G0S2 G0/G1 switch 2 [Homo sapiens]
Gene ID:50486

Gene

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