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Agonist activity at human CXCR3
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human wild type CXCR3
Assay data:4 Active, 4 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human recombinant CXCR3
Assay data:2 Active, 2 Activity ≤ 1 µM, 3 Tested
Displacement of [125I]-CXCL10 from CXCR3 in human PBMC cells
Assay data:19 Active, 3 Activity ≤ 1 nM, 18 Activity ≤ 1 µM, 20 Tested
Antagonist activity at CXCR3 (unknown origin) by flow cytometry method
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Antagonist activity at CXCR3 (unknown origin)
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Antagonist activity at CXCR3 (unknown origin) assessed as reduction in CXCL10 induced calcium flux by FLIPR method
Assay data:6 Active, 1 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 6 Tested
Antagonist activity at CXCR3 (unknown origin) assessed as reduction in CXCL11 induced calcium flux by FLIPR method
Assay data:8 Active, 7 Activity ≤ 1 µM, 9 Tested
Antagonist activity at CXCR3 (unknown origin) assessed as reduction in CXCL10 induced calcium flux by [35S]GTPgammaS binding assay
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Antagonist activity at CXCR3 (unknown origin) assessed as reduction in CXCL10 induced calcium flux by flow cytometry
Antagonist activity at CXCR3 (unknown origin) assessed as reduction in CXCL11 induced calcium flux by flow cytometry
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Displacement of [125I]-CXCL10 from CXCR3 in human PBMC cells by scintillation proximity assay
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
Antagonist activity at human CXCR3 assessed as reduction in CXCL11 induced calcium flux by [35S]GTPgammaS binding assay
Binding affinity to CXCR3 (unknown origin) at 10 uM by radioligand binding assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Antagonist activity at CXCR3 in human whole blood assessed as receptor internalization incubated for 30 mins in presence of CXCL10 by flow cytometric analysis
Binding affinity to human CXCR3 expressed in CHO-K1 cell membrane assessed as dissociation rate constant (koff) using tritium-labeled ligand by FLIPR assay
Binding affinity to human CXCR3 expressed in CHO-K1 cell membrane assessed as absorption rate constant (Kon) using tritium-labeled ligand by FLIPR assay
Binding affinity to human CXCR3 expressed in CHO-K1 cell membrane assessed as dissociation constant using tritium-labeled ligand by FLIPR assay
Antagonist activity at human CXCR3 expressed in CHO-K1 cells assessed as reduction in CXCL11 induced calcium flux by FLIPR method
Antagonist activity at human CXCR3 expressed in CHO-K1 cells assessed as reduction in CXCL10 induced calcium flux by FLIPR method
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