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Invivo inhibition of ASK1 in Tg4510 mouse model of Alzheimer's disease assessed as reduction in MCP-1 levels in cortex at 3 to 30 mg/kg, po BID for 3 days measured after 4 hrs post last dose by ELISA
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Invivo inhibition of ASK1 in Tg4510 mouse model of Alzheimer's disease assessed as reduction in IL-1beta levels in cortex at 3 to 30 mg/kg, po BID for 3 days measured after 4 hrs post last dose by ELISA
Binding affinity to ASK1 in mouse brain lysates at 30 mg/kg, po BID for 3 days by nanoLS-MS/MS based cellular target engagement assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Invivo inhibition of ASK1 in Tg4510 mouse model of Alzheimer's disease assessed as reduction in KC/GRO levels in cortex at 3 to 30 mg/kg, po BID for 3 days measured after 4 hrs post last dose by ELISA
In vivo inhibition of ASK1 in DSS-induced ulcerative colitis ICR mouse model assessed as downregulation of phosphorylation of JNK in colon at 25 mg/kg, po qd measured after 7 days by western blot assay
Assay data:2 Active, 2 Tested
In vivo inhibition of ASK1 in DSS-induced ulcerative colitis ICR mouse model assessed as downregulation of phosphorylation of p38 in colon at 25 mg/kg, po qd measured after 7 days by western blot assay
In vivo inhibition of ASK1 in DSS-induced ulcerative colitis ICR mouse model assessed as downregulation of phosphorylation of MKK4/7 in colon at 25 mg/kg, po qd measured after 7 days by western blot assay
In vivo inhibition of ASK1 in DSS-induced ulcerative colitis ICR mouse model assessed as downregulation of phosphorylation of MKK3/6 in colon at 25 mg/kg, po qd measured after 7 days by western blot assay
In vivo inhibition of ASK1 in DSS-induced ulcerative colitis ICR mouse model assessed as downregulation of phosphorylation of ASK1 in colon at 25 mg/kg, po qd measured after 7 days by western blot assay
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout
Assay data:762 Active, 16821 Tested
SummaryRelated BioAssays by Same Project
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout
Assay data:1106 Active, 16821 Tested
A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen
Assay data:788 Active, 16789 Tested
SummaryPubMed Citation
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