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Chaperone activity at GALNS in human fibroblasts assessed as change in lysosomal mass at 0.01 to 10 uM incubated for 36 hrs by deep red Lysotracker based flow cytometric analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Chaperone activity at recombinant human GALNS expressed in HEK293 cells assessed as fold increase in extracellular enzyme activity using 4MUGPS as substrate at 10 uM incubated for 48 hrs by fluorescence assay relative to control
Chaperone activity at recombinant human GALNS expressed in HEK293 cells assessed as fold increase in extracellular enzyme activity using 4MUGPS as substrate at 1 uM incubated for 48 hrs by fluorescence assay relative to control
Inhibition of recombinant human GALNS expressed in Pichia pastoris at 0.001 to 50 uM using 4MUGPS as substrate incubated for 18 hrs by fluorescence assay relative to control
Chaperone activity at recombinant human GALNS expressed in Pichia pastoris assessed as increase in extracellular enzyme level by bioreactor-based assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Chaperone activity at recombinant human GALNS expressed in HEK293 cells assessed as increase in GALNs level at 0.001 mM measured after 48 hrs by LysoTracker Green DND-26/DAPI staining based immunofluorescence assay
Assay data:2 Active, 2 Tested
Chaperone activity at recombinant human GALNS expressed in HEK293 cells assessed as increase in extracellular enzyme activity at 0.001 uM using 4-methylumbelliferyl-beta-D-galactopyranoside-6-sulfate as substrate measured after 48 hrs by fluorescence assay relative to control
Assay data:2 Tested
Chaperone activity at recombinant human GALNS expressed in HEK293 cells assessed as increase in intracellular enzyme activity at 0.001 uM using 4-methylumbelliferyl-beta-D-galactopyranoside-6-sulfate as substrate measured after 48 hrs by fluorescence assay
Chaperone activity at recombinant human GALNS expressed in HEK293 cells assessed as increase in extracellular enzyme activity at 0.01 uM using 4-methylumbelliferyl-beta-D-galactopyranoside-6-sulfate as substrate measured after 48 hrs by fluorescence assay relative to control
Chaperone activity at recombinant human GALNS expressed in HEK293 cells assessed as increase in intracellular enzyme activity at 0.01 uM using 4-methylumbelliferyl-beta-D-galactopyranoside-6-sulfate as substrate measured after 48 hrs by fluorescence assay relative to control
Chaperone activity at recombinant human GALNS expressed in Pichia pastoris assessed as increase in extracellular enzyme activity at 0.001 uM using 4-methylumbelliferyl-beta-D-galactopyranoside-6-sulfate as substrate treated every 24 hrs for 96 hrs by fluorescence assay relative to control
Chaperone activity at recombinant human GALNS expressed in Escherichia coli BL21 (DE3) assessed as increase in extracellular enzyme activity at 0.001 to 1 uM using 4-methylumbelliferyl-beta-D-galactopyranoside-6-sulfate as substrate measured after 24 hrs by fluorescence assay relative to control
Chaperone activity at recombinant human GALNS expressed in Escherichia coli BL21 (DE3) assessed as increase in intracellular enzyme activity at 0.001 to 1 uM using 4-methylumbelliferyl-beta-D-galactopyranoside-6-sulfate as substrate measured after 24 hrs by fluorescence assay
Stabilization of recombinant human GALNS expressed in Pichia pastoris assessed as melting temperature at 1 uM by SYPRO orange dye based fluorescence assay (Rvb = 62.8 degC)
Inhibition of recombinant human GALNS expressed in Pichia pastoris at 10 uM using 4-methylumbelliferyl-beta-D-galactopyranoside-6-sulfate as substrate measured after 18 hrs by fluorescence assay relative to control
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
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