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Drug metabolism assessed as Sprague-Dawley rat pyruvate kinase M-mediated drug conversion
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inactivation of Sprague-Dawley rat pyruvate kinase M using PEP as substrate at 7 mM pretreated at 22 degC for 2 hrs with pyruvate kinase L measured for 3.5 hrs by spectrophotometric analysis
Inactivation of Sprague-Dawley rat pyruvate kinase M using PEP as substrate at 5 mM at pH 7 after 24 hrs by spectrophotometric analysis
Inactivation of Sprague-Dawley rat pyruvate kinase M using PEP as substrate at 5 mM at pH 7 after 8 hrs by spectrophotometric analysis
Assay data:6 Tested
Activity at Sprague-Dawley rat pyruvate kinase M assessed as initial enzyme reaction velocity at 0.21 mM by spectrophotometric analysis relative to ADP
Assay data:5 Tested
Ratio of Km(ADP)/Ki or Km for rat muscle pyruvatre kinase; (inhibitory potency at 2.35 mM)
Ratio of Km(ADP)/Ki or Km for rat muscle pyruvate kinase
Assay data:13 Tested
Relative half maximal velocity of Pyruvate kinase and Phosphoenolpyruvate
Assay data:2 Tested
Assay data:16 Tested
Inhibition of rat muscle pyruvate kinase (PK-M) at 6.7 mM
Inhibition of rat muscle pyruvate kinase (PK-M) at 10 mM
Inhibition of rat muscle pyruvate kinase (PK-M)
Michaelis-Menten constant for inhibition of pyruvate kinase obtained from rat muscle (PK-M) was determined using ADP as competitive inhibitor
Assay data:10 Tested
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