Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
Electrophysiology Assay from US Patent US20240002393: "SUBSTITUTED BENZO[f][l ,2,4JTRIAZOL0[4,3-a][l ,4JDIAZEPINES AS GABA A GAMMA! POSITIVE ALLOSTERIC MODULATORS"
Assay data:44 Active, 44 Activity ≤ 1 µM, 44 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Binding Assay for γ2-Containing GABAA Subtypes from US Patent US20240002393: "SUBSTITUTED BENZO[f][l ,2,4JTRIAZOL0[4,3-a][l ,4JDIAZEPINES AS GABA A GAMMA! POSITIVE ALLOSTERIC MODULATORS"
Assay data:44 Active, 7 Activity ≤ 1 nM, 44 Activity ≤ 1 µM, 44 Tested
Selectivity interaction (Eurofins-Panlabs panel (at Boehringer Ingelheim)) EUB0000314b GABRB2
Assay data:1 Tested
SummaryRelated BioAssays by Target
Binding affinity to GABAA receptor (unknown origin) at 10000 nM by radioligand displacement assay relative to control
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of alpha2beta2gamma2 GABAA receptor (unknown origin) relative to control
Inhibition of alpha1beta2gamma2 GABAA receptor (unknown origin) relative to control
Positive allosteric modulation of recombinant GABAA alpha1beta2 receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induced chloride current at -70 mV holding potential in presence of GABA EC3 to 7 by two-microelectrode voltage-clamp assay relative to control
Positive allosteric modulation of recombinant GABAA alpha1beta2 receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induced chloride current at -70 mV holding potential in presence of GABA EC3 to 7 by two-microelectrode voltage-clamp assay
Positive allosteric modulation of recombinant GABAA alpha1beta2gamma2 receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induced chloride current at -70 mV holding potential in presence of GABA EC3 to 7 by two-microelectrode voltage-clamp assay relative to control
Positive allosteric modulation of recombinant GABAA alpha1beta2gamma2 receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induced chloride current at -70 mV holding potential in presence of GABA EC3 to 7 by two-microelectrode voltage-clamp assay
Additive positive allosteric modulation of GABAA alpha1beta2gamma2 receptor (unknown origin) stably expressed in CHO cells assessed as activation of GABA-induced response at 0.5 to 4 uM in presence of allopregnanolone by FLIPR assay
Positive allosteric modulation of GABAA alpha1beta2gamma2 receptor (unknown origin) stably expressed in CHO cells assessed as activation of GABA-induced response at 10 uM in presence of pregnenolone sulfate by FLIPR assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Additive positive allosteric modulation of GABAA alpha1beta2gamma2 receptor (unknown origin) stably expressed in CHO cells assessed as activation of GABA-induced response at 0.5 to 8 uM in presence of etazolate by FLIPR assay
Additive positive allosteric modulation of GABAA alpha1beta2gamma2 receptor (unknown origin) stably expressed in CHO cells assessed as activation of GABA-induced response at 0.5 to 8 uM in presence of diazepam by FLIPR assay
Positive allosteric modulation of GABAA alpha1beta2gamma2 receptor (unknown origin) stably expressed in CHO cells assessed as activation of GABA-induced response at 5 uM in presence of flumazenil by FLIPR assay
Positive allosteric modulation of GABAA alpha1beta2gamma2 receptor (unknown origin) stably expressed in CHO cells assessed as activation of GABA-induced response up to 640 mM by FLIPR assay
Positive allosteric modulation of GABAA alpha1beta2gamma2 receptor (unknown origin) stably expressed in CHO cells assessed as activation of GABA-induced response at 0.5 uM in presence of pregnenolone sulfate by FLIPR assay
Positive allosteric modulation of GABAA alpha1beta2gamma2 receptor (unknown origin) stably expressed in CHO cells assessed as activation of GABA-induced response at 2 uM in presence of flumazenil by FLIPR assay
Positive allosteric modulation of GABAA alpha1beta2gamma2 receptor (unknown origin) stably expressed in CHO cells assessed as activation of GABA-induced response in presence of GABA by FLIPR assay
Assay data:5 Active, 1 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Positive allosteric modulation of GABAA alpha1beta2gamma2 receptor (unknown origin) stably expressed in CHO cells assessed as activation of GABA-induced response at 20 uM in presence of GABA by FLIPR assay relative to control
Assay data:6 Tested
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on