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Increase in translocation of GAA to lysosome in human F2845 cells at 1 uM after 5 days by confocal laser-scanning microscopic analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of alpha-glucosidase in human HepG2 cells assessed as increase in expression of immature high mannose type N-linked oligosachcharides at 500 uM after 48 hrs by MALDI-TOF MS analysis relative to untreated control
Assay data:1 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human recombinant GAA assessed as hydrolysis of bovine liver glycogen by Amplex red oxidase assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity at wild type recombinant GAA assessed as thermostabilization of protein at 50 uM incubated at 66 degC for 60 mins
Assay data:2 Active, 2 Tested
Inhibition of wild type recombinant GAA preincubated for 5 mins measured after 45 mins using blue-shifted dye by fluorescence assay
Assay data:7 Active, 1 Activity ≤ 1 µM, 34 Tested
Inhibition of wild type recombinant GAA preincubated for 5 mins measured after 45 mins using red-shifted dye by fluorescence assay
Binding affinity at wild type recombinant GAA assessed as rise in melting temperature of protein using SYPRO Orange dye by fluorescence assay
Increase in translocation of GAA to lysosomes in human wild type skin fibroblasts at 1 to 5 uM after 5 days by confocal laser-scanning microscopic analysis
Increase in translocation of GAA to lysosomes in human F2845 cells at 1 to 5 uM after 5 days by confocal laser-scanning microscopic analysis
Increase in translocation of GAA to lysosomes in human wild type fibroblasts at 15 uM after 6 days confocal laser-scanning microscopic analysis
Binding affinity at wild type recombinant NT-495 labelled GAA incubated for 15 mins by microscale thermophoresis assay
Assay data:2 Tested
Increase in translocation of GAA to lysosomes in human wild type skin fibroblasts at 5 uM after 6 days by confocal laser-scanning microscopic analysis
Increase in translocation of GAA to lysosome in human F2845 cells at 5 uM after 5 days by confocal laser-scanning microscopic analysis
Assay data:1 Active, 1 Tested
Increase in translocation of GAA to lysosome in human F0833 cells at 5 uM after 5 days by confocal laser-scanning microscopic analysis
Increase in translocation of GAA to lysosome in human F3248 cells at 5 uM after 5 days by confocal laser-scanning microscopic analysis
Inhibition of pure alpha-glucosidase (unknown origin) assessed as para-nitrophenol release at 420 nm OD
Assay data:12 Tested
Increase in GAA activity in human wild type skin fibroblasts incubated for 5 days followed by 18 to 40 hrs wash out by fluorescence assay relative to vehicle-treated control
Increase in GAA activity in human F2845 cells incubated for 5 days followed by 18 to 40 hrs wash out by fluorescence assay relative to vehicle-treated control
Increase in GAA activity in human F2845 cells incubated for 5 days by fluorescence assay relative to vehicle-treated control
Increase in translocation of GAA to lysosome in human F0833 cells at 1 uM after 5 days by confocal laser-scanning microscopic analysis
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