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Inhibition of HuMetAP1 using Met-Pro-pNA as substrate by spectrophotometer based analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Enzymatic Assay from Article 10.1016/j.chembiol.2007.05.010: "Regulation of c-Src nonreceptor tyrosine kinase activity by bengamide A through inhibition of methionine aminopeptidases."
Assay data:3 Active, 6 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
MetAP Inhibition Assay from Article 10.1073/pnas.0608389103: "Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression."
Assay data:4 Active, 5 Tested
MetAP Enzyme Activity Assay from Article : "Tumor suppression by a rationally designed reversible inhibitor of methionine aminopeptidase-2."
Assay data:9 Active, 6 Activity ≤ 1 µM, 9 Tested
Binding affinity to human MetAP1 expressed in Escherichia coli BL21 (DE3) by surface plasmon resonance analysis
Assay data:4 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
Inhibition of human MetAP1 expressed in Escherichia coli BL21 (DE3) using L-methionine-4-methyl-coumary1-7-amide as substrate preincubated for 30 mins followed by substrate addition and measured at 1 min interval for 30 mins by spectrofluorometric method
Assay data:1 Active, 16 Tested
Inhibition of N-terminal MetAP1 (unknown origin)
Assay data:26 Tested
SummaryPubMed CitationRelated BioAssays by Target
Stability in pH 2 HCl assessed as aminopeptidase (unknown origin)-mediated compound hydrolysis by measuring parent compound remaining at 200 uM up to 6 hrs by RP-HPLC analysis
Assay data:1 Tested
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Inhibition of human MetAP1
Assay data:5 Active, 4 Activity ≤ 1 µM, 6 Tested
Human Methionyl aminopeptidase 1 (M24: Methionyl aminopeptidase)
Assay data:1 Active, 1 Tested
Inhibition of recombinant full length human His-tagged methionine aminopeptidase 1 expressed in Escherichia coli BL21(DE3) using methionylprolyl-p-nitroanilide as substrate preincubated for 20 mins followed by substrate addition measured for 20 mins in presence of CoCl2 by proline aminopeptidase coupled enzyme assay
Assay data:4 Tested
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
Inhibition of Human MetAP1b using Met-pNA as substrate
Assay data:2 Active, 6 Tested
Inhibition of N-terminal poly-His-tagged human MetAP-1 expressed in Escherichia coli BL21(DE3) incubated for 30 mins before MGMM substrate addition by fluorescence assay
Assay data:3 Active, 1 Activity ≤ 1 µM, 32 Tested
Inhibition of human MetAP at 25 uM after 20 mins by HPLC analysis
Assay data:71 Tested
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
InfectX: Pathogen infection siRNA screens
Assay data:115372 Tested
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