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Inhibition of TNIK (unknown origin) at 10 uM by biochemical hotspot kinase assay relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of TNIK (unknown origin) by Ambit kinase assay
Inhibition of TNIK (unknown origin) at 10 uM relative to control
TNIK Human STE Kinase Enzymatic Radiometric Assay from US Patent US11530199: "Analogs for the treatment of disease"
Assay data:39 Active, 45 Activity ≤ 1 µM, 45 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
TNIK Human STE Kinase Enzymatic Radiometric Assay from US Patent US11530197: "Analogs for the treatment of disease"
Inhibition of TNIK (unknown origin) at 100 nM by KINOMEscan assay relative to control
Inhibition of TNIK (unknown origin)
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of TNIK (unknown origin) at 0.1 uM relative to control
Inhibition of TNIK signalling pathway in human HCT-116 cells assessed as expression of TNIK level at 5 to 40 uM measured after 48 hrs by Western blot analysis
Inhibition of human recombinant TNIK (1 to 367 residues) using RLGRDKYKTLRQIRQ as substrate in presence of ATP incubated for 40 mins by radiometric based scintillation method
Assay data:34 Active, 25 Activity ≤ 1 µM, 54 Tested
Assay data:3 Active, 2 Activity ≤ 1 µM, 5 Tested
Inhibition of human recombinant TNIK (1 to 367 residues) using RLGRDKYKTLRQIRQ as substrate incubated for 40 mins in presence of Mg/ATP mix by [gamma p33]-ATP based radiometric scintillation counting method
Assay data:27 Active, 15 Activity ≤ 1 µM, 39 Tested
Inhibition of TNIK (unknown origin) at 1 uM relative to control
TNIK DiscoveRx kinase panel
SummaryRelated BioAssays by Target
TNIK(h) Kinase panel
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of TNIK (unknown origin) at 1 uM
Inhibition of TNIK (unknown origin) at 1 uM by kinome scan method
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
ADP-Glo Kinase Assay from US Patent US11485711: "Compounds for inhibiting TNIK and medical uses thereof"
Assay data:140 Active, 4 Activity ≤ 1 nM, 140 Activity ≤ 1 µM, 140 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
In Vitro TNIK Kinase Assay from US Patent US11447469: "Hetero ring-fused phenyl compounds for inhibiting TNIK and medical uses thereof"
Assay data:10 Active, 3 Activity ≤ 1 nM, 10 Activity ≤ 1 µM, 10 Tested
TNIK Inhibition Assay from US Patent US11739078: "Methods of inhibiting kinases"
Assay data:117 Active, 108 Activity ≤ 1 µM, 124 Tested
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