Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
Induction of cereblon-mediated aiolos degradation in human OPM2 cells at 0.01 to 1 uM after 5 hrs by immunoblot analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Induction of CRBN-mediated pLOC-ePL-tagged aiolos (unknown origin) degradation in human DF15 cells assessed as minimum protein remaining incubated for 4 hrs by luminescence based beta-galactosidase enzyme fragmentation complementation assay
Assay data:33 Active, 27 Activity ≤ 1 nM, 35 Activity ≤ 1 µM, 36 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Protac activity at cereblon/IKZF3 in human SW480 cells assessed as induction of IKZF1 degradation at 5 to 10 uM incubated for 24 hrs by Western blot assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Protac activity at VHL/IKZF3 in human MM1S cells assessed as IKZF3 degradation at 100 nM after 4 hrs by Western blot analysis
Induction of CRBN ubiquitin ligase-mediated IKZF3 degradation in human U266 cells up to 1000 nM measured after 12 hrs by immunoblotting analysis
Induction of CRBN ubiquitin ligase-mediated IKZF3 degradation in human NCI-H929 cells up to 1000 nM by immunoblotting analysis
Assay data:2 Active, 5 Tested
Inhibition of CRBN-mediated IKFZ3 degradation in human OPM2 cells measured after 24 hrs by Western blot analysis
Assay data:19 Tested
Inhibition of CRBN-mediated IKFZ3 degradation in human OPM2 cells at 100 uM measured after 24 hrs by Western blot analysis relative to control
Assay data:4 Tested
Protac activity at CRBN/IKZF3 in human MM1S cells assessed as IKZF3 degradation at 100 nM measured after 6 hrs in presence of NAE inhibitor MLN 4924 by Western blot analysis
Protac activity at CRBN/IKZF3 in human MM1S cells assessed as IKZF3 degradation at 100 nM measured after 6 hrs in presence of E3 ligase ligand pomalidomide by Western blot analysis
Protac activity at CRBN/IKZF3 in human MM1S cells assessed as IKZF3 degradation at 100 nM measured after 6 hrs in presence of HDAC6 inhibitor Next-A by Western blot analysis
Protac activity at CRBN/IKZF3 in human MM1S cells assessed as IKZF3 degradation at 100 nM incubated for 6 hrs followed by compound washout and measured after 12 hrs by Western blot analysis
Protac activity at CRBN/IKZF3 in human MM1S cells assessed as IKZF3 degradation measured after 6 hrs by Western blot analysis
Protac activity at CRBN/IKZF3 in human MM1S cells assessed as IKZF3 degradation at 100 nM measured after 4 hrs by Western blot analysis
Protac activity at CRBN/IKZF3 in human MM1S cells assessed as IKZF3 degradation at 100 nM measured after 6 hrs by Western blot analysis
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Induction of CRBN-mediated pLOC-ePL-tagged aiolos (unknown origin) degradation in human DF15 cells assessed as minimum protein remaining up to 10 uM incubated for 4 hrs by luminescence based beta-galactosidase enzyme fragmentation complementation assay relative to control
Assay data:39 Tested
Induction of cereblon-mediated aiolos degradation in human DF15 cells at 0.01 to 1 uM after 5 hrs by immunoblot analysis
Induction of cereblon-mediated aiolos degradation in human OPM2 cells at 0.1 to 10 uM after 5 hrs by immunoblot analysis
Assay data:2 Active, 2 Tested
Induction of cereblon-mediated aiolos degradation in human DF15 cells at 0.1 to 10 uM after 5 hrs by immunoblot analysis
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on