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Summary
SPR Assay to Characterize Ternary Complex Formation with FKBP12 from US Patent US11603377: "MTORC1 modulators and uses thereof"
Assay data:45 Active, 63 Activity ≤ 1 µM, 63 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
SPR Assay to Determine Binding Affinity to FKBP12 from US Patent US11603377: "MTORC1 modulators and uses thereof"
Assay data:50 Active, 64 Activity ≤ 1 nM, 64 Activity ≤ 1 µM, 64 Tested
Binding affinity to FKBP12 (unknown origin) assessed as inhibition constant
Assay data:7 Active, 6 Activity ≤ 1 µM, 7 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human full length recombinant mTOR/FKBP12 in presence of [gamma-33P]ATP incubated for 40 mins by radiometric scintillation counting analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
PROTAC activity at CRBN/FKBP12 in human Jurkat cells assessed as induction of FKBP12 degradation incubated for 12 hrs by Western blot analysis
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
NanoBRET assay (FKBP12-NLuc) (FKBP1A)
Assay data:1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, activity ≤ 1 µMRelated BioAssays by Target
NanoBRET assay (FKBP51-NLuc) (FKBP1A)
Assay data:1 Tested
SummaryRelated BioAssays by Target
Competitive fluorescence polarization binding assay (FKBP1A)
mTOR/FKBP12(h) Kinase panel
SPR Protocol to Measure Binding of a Compound to FKBP12 from US Patent US11059830: "Compounds that participate in cooperative binding and uses thereof"
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
Binding of Compounds to FKBP12 from US Patent US11059830: "Compounds that participate in cooperative binding and uses thereof"
Assay data:10 Active, 4 Activity ≤ 1 nM, 10 Activity ≤ 1 µM, 10 Tested
PPlase Assay from US Patent US9505773: "Rapamycin analogues and their pharmaceutical use"
Assay data:18 Active, 18 Activity ≤ 1 µM, 18 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
FKBP12 Assay from Article 10.1016/1074-5521(95)90264-3: "Structure-activity studies of rapamycin analogs: evidence that the C-7 methoxy group is part of the effector domain and positioned at the FKBP12-FRAP interface."
Assay data:21 Active, 6 Activity ≤ 1 nM, 21 Activity ≤ 1 µM, 21 Tested
Peptidyl Prolyl Isomerase (PPIase) Inibition Assay from Article 10.1021/jm049161u: "Design, synthesis, and biological activity of novel polycyclic aza-amide FKBP12 ligands."
Assay data:60 Active, 55 Activity ≤ 1 µM, 62 Tested
mTOR/FKBP12(h) Eurofins kinase panel
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