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FGFR3 SGC Tm panel (DSF)
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of FGFR3 (unknown origin) at 10 uM by biochemical hotspot kinase assay relative to control
Inhibition of FGFR (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of FGFR3 (unknown origin) at 1 uM relative to control
Inhibition of recombinant N-terminal His-Avi-tag human FGFR3 (447 to 761 residues) expressed in Sf9 infected baculovirus expression system using biotin-EQEDEPEGDYFEWLE-amide as substrate preincubated for 5 to 10 mins followed by substrate addition and measured after 1 hr in presence of ATP by HTRF assay
Assay data:18 Active, 18 Activity ≤ 1 µM, 18 Tested
Inhibition of wild type human partial length FGFR3 (R442 to S771 residues) expressed in bacterial expression system at 100 uM by Kinome scan method relative to control
Inhibition of human FGFR3
Inhibition of human recombinant GST-fused FGFR3 expressed in baculovirus expression system using poly-Glu-Tyr (4:1) as substrate measured after 10 mins in presence of gamma-[33P]-ATP by scintillation counting analysis
Assay data:2 Active, 2 Tested
Assay data:3 Tested
Inhibition of FGFR3 (unknown origin) assessed as dissociation constant
Inhibition of FGFR3 V555M mutant (unknown origin)
Assay data:1 Active, 1 Tested
Inhibition of FGFR phosphorylation in human SNU-16 cells at 5 nM measured after 24 hrs
Inhibition of FGFR phosphorylation in human SNU-16 cells at 5 nM measured after 12 hrs
Inhibition of FGFR signalling in human SNU-16 assessed as inhibition of PLCgamma phosphorylation at 0.1 nM incubated for 2 hrs by Western blot analysis
Inhibition of FGFR signalling in human SNU-16 assessed as inhibition of pErk phosphorylation at 0.1 nM incubated for 2 hrs by Western blot analysis
Inhibition of FGFR3 (unknown origin) using Poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins in presence of ATP by ELISA analysis
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of FGFR3 (unknown origin)
Inhibition of human recombinant FGFR3
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
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