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Inhibition of ALKBH3 (unknown origin) at 50 uM relative to control
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of ALKBH3 (unknown origin) using 3-methyl cytosine oligo DNA as substrate incubated for 1 hr by SYBR green dye based RT-PCR analysis
Assay data:1 Active, 1 Tested
Inhibition of human ALKBH3 demethylase activity by restriction endonuclease digestion assay
Inhibition of human ALKBH3 by HPLC analysis
Inhibition of human ALKBH3 expressed in Escherichia coli BL21 (DE3) Rosetta cells
Assay data:2 Active, 10 Tested
Inhibition of N-terminal His-tagged human ALKBH3 (1 to 286 residues) using m6A-ssDNA as substrate incubated for 30 mins by MALDI-TOF-MS analysis
Assay data:3 Tested
Inhibition of human ALKBH3 using ss-m1A DNA as substrate by HPLC analysis
Assay data:2 Tested
Inhibition of human full lenth N-terminal His6-tagged ALKBH3 (1 to 286 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Inhibition of AlkBH3 in human A549 cells assessed as increase in MMS-induced cytotoxicity at 1 uM after 48 hrs by MTT assay
Assay data:1 Active, 3 Tested
Mixed type inhibition of recombinant human AlkBH3 assessed as reduction in formaldehyde release at 50 to 500 uM using varying levels of 2OG as substrate incubated for 60 mins followed by substrate addition measured after 15 mins by Lineweaver-Burk plot analysis
Competitive inhibition of recombinant human AlkBH3 assessed as reduction in formaldehyde release at 50 to 500 uM using 40-mer internal N3me-oligo-dC as substrate incubated for 60 mins followed by substrate addition measured after 15 mins by Lineweaver-Burk plot analysis
Binding affinity to recombinant human AlkBH3 incubated for 2 mins by isothermal titration calorimetric method
Binding affinity to recombinant human AlkBH3 at 12 uM after 1 hr by near-UV circular dichroism spectroscopy
Binding affinity to recombinant human AlkBH3 at 12 uM after 1 hr by far-UV circular dichroism spectroscopy
Inhibition of recombinant human AlkBH3 assessed as reduction in formaldehyde release at 50 uM using 40-mer single N3-meC as substrate incubated for 60 mins followed by substrate addition measured after 15 mins by fluorescence assay
Assay data:3 Active, 3 Tested
Inhibition of recombinant human AlkBH3 assessed as reduction in formaldehyde release using 40-mer single N3-meC as substrate incubated for 60 mins followed by substrate addition measured after 15 mins by fluorescence assay
Assay data:1 Active, 25 Tested
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
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