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Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assay
Assay data:13 Active, 1 Activity ≤ 1 nM, 11 Activity ≤ 1 µM, 16 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity against TRH-R receptor in AtT-20 mouse pituitary tumor cells
Assay data:4 Active, 2 Activity ≤ 1 µM, 4 Tested
Ability to activate thyroliberin endocrine receptor (TRH-R) using AtT-20 mouse pituitary tumor cells prelabelled with myo-[3H] inositol
Assay data:3 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 3 Tested
Ability to bind thyroliberin endocrine receptor (TRH-R) using AtT-20 mouse pituitary tumor cells.
Assay data:3 Active, 1 Activity ≤ 1 µM, 4 Tested
Effective concentration required to activate TRH-R receptor in AtT-20 mouse pituitary tumor cells
Assay data:3 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Displacement of [3H]MeTRH from Thyrotropin releasing hormone receptor 1 was measured; expressed as %
Assay data:11 Tested
A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen
Assay data:788 Active, 16789 Tested
SummaryPubMed Citation
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout
Assay data:1106 Active, 16821 Tested
SummaryRelated BioAssays by Same Project
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Secondary screen TNF readout
Assay data:2176 Active, 3847 Tested
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout
Assay data:762 Active, 16821 Tested
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Secondary screen NFkB readout
Assay data:1483 Active, 3847 Tested
Displacement of [3H]-1-MeHis-TRH from mouse TRH-R1 expressed in HEK293 cells incubated up to 4 hrs by scintillation counting method
Assay data:1 Active, 1 Activity ≤ 1 µM, 18 Tested
Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as induction of changes in intracellular Ca2+ level by FLIPR method
Assay data:16 Active, 1 Activity ≤ 1 nM, 11 Activity ≤ 1 µM, 18 Tested
Displacement of [3H]-Me-His-TRH from mouse TRH-R1 expressed in HEK293 cells preincubated for 15 mins measured after 4 hrs
Assay data:4 Active, 3 Activity ≤ 1 µM, 16 Tested
Mouse TRH1 receptor (Thyrotropin-releasing hormone receptors)
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISA
Assay data:10 Active, 9 Activity ≤ 1 µM, 16 Tested
Displacement of [3H]-Me-His-TRH from wild type TRHR mouse brain membranes at 10 uM after 4 hrs by scintillation counting method
Assay data:2 Tested
Displacement of [3H]-Me-His-TRH from wild type TRHR mouse brain membranes at 1 uM after 4 hrs by scintillation counting method
Displacement of [3H]-Me-His-TRH from wild type TRHR mouse brain membranes at 0.1 uM after 4 hrs by scintillation counting method
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