BioAssay by Target (List) for Gene (Select 2171) - PubChem BioAssay - NCBI

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Select item 19587681.

Inhibition of FABP5 (unknown origin)

Source:: ChEMBL

Protein Target:: Fatty acid-binding protein 5

Assay data:11 Active, 8 Activity ≤ 1 µM, 14 Tested

AID:: 1958768

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19587672.

Inhibition of human FABP5

Source:: ChEMBL

Protein Target:: Fatty acid-binding protein 5

Assay data:6 Active, 5 Activity ≤ 1 µM, 6 Tested

AID:: 1958767

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19587633.

Inhibition of FABP5 (unknown origin) by fluorescence polarization assay

Source:: ChEMBL

Protein Target:: Fatty acid-binding protein 5

Assay data:4 Active, 6 Tested

AID:: 1958763

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 19493644.

Inhibition of FABP5 (unknown origin) assessed as inhibition constant

Source:: ChEMBL

Protein Target:: Fatty acid-binding protein 5

Assay data:3 Active, 1 Activity ≤ 1 µM, 4 Tested

AID:: 1949364

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19200045.

FABP3, FABP5, and FABP7 Binding Assay from US Patent US20230365488: "TRUXILLIC ACID MONOESTER-DERIVATIVES AS SELECTIVE FABP5 INHIBITORS AND PHARMACEUTICAL COMPOSITIONS AND USES THEREOF"

Source:: BindingDB

Protein Targets:: FABP3 protein; ...
Total:: 3

Assay data:47 Active, 22 Activity ≤ 1 µM, 47 Tested

AID:: 1920004

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 18544306.

Inhibition of human FABP5

Source:: ChEMBL

Protein Target:: Fatty acid-binding protein 5

Assay data:1 Tested

AID:: 1854430

Summary PubMed Citation Related BioAssays by Target

Select item 18054167.

High Throughput Fluorescence Displacement Assay from US Patent US10968163: "Alpha-truxillic acid derivatives and pharmaceutical compositions thereof"

Source:: BindingDB

Protein Targets:: Fatty acid-binding protein 5; ...
Total:: 3

Assay data:34 Active, 33 Activity ≤ 1 µM, 34 Tested

AID:: 1805416

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 18030118.

Time Resolved-Fluorescence Energy Transfer (TR-FRET) Assay from US Patent US9353102: "Non-annulated thiophenylamides"

Source:: BindingDB

Protein Targets:: Fatty acid-binding protein 5; ...
Total:: 2

Assay data:42 Active, 40 Activity ≤ 1 µM, 42 Tested

AID:: 1803011

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 18028329.

Ligand Binding Assay from Article 10.1074/jbc.M113.514646: "Structural basis for ligand regulation of the fatty acid-binding protein 5, peroxisome proliferator-activated receptor /d (FABP5-PPAR /d) signaling pathway."

Source:: BindingDB

Protein Targets:: Fatty acid-binding protein 5; ...
Total:: 1

Assay data:6 Active, 2 Activity ≤ 1 µM, 6 Tested

AID:: 1802832

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 180238410.

Time Resolved-Fluorescence Energy Transfer (TR-FRET) Assay from US Patent US9278918: "Urea derivatives and their use as fatty-acid binding protein (FABP) inhibitors"

Source:: BindingDB

Protein Targets:: Fatty acid-binding protein 5; ...
Total:: 2

Assay data:16 Active, 14 Activity ≤ 1 µM, 16 Tested

AID:: 1802384

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 179639111.

Time Resolved-Fluorescence Energy Transfer (TR-FRET) Assay from US Patent US9604977: "Bicyclic thiophenylamide compounds"

Source:: BindingDB

Protein Targets:: Fatty acid-binding protein 5; ...
Total:: 2

Assay data:251 Active, 212 Activity ≤ 1 µM, 251 Tested

AID:: 1796391

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 177321812.

Binding affinity to FABP5 (unknown origin) by microscale thermophoresis analysis

Source:: ChEMBL

Protein Target:: Fatty acid-binding protein 5

Assay data:3 Tested

AID:: 1773218

Summary PubMed Citation Related BioAssays by Target

Select item 177319213.

Displacement of 1,8-ANS from FABP5 (unknown origin) incubated for 3 mins by fluorescence based analysis

Source:: ChEMBL

Protein Target:: Fatty acid-binding protein 5

Assay data:11 Active, 30 Tested

AID:: 1773192

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 177319014.

Displacement of 1,8-ANS from FABP5 (unknown origin) at 25 uM incubated for 3 mins by fluorescence based analysis relative to control

Source:: ChEMBL

Protein Target:: Fatty acid-binding protein 5

Assay data:30 Tested

AID:: 1773190

Summary PubMed Citation Related BioAssays by Target

Select item 171641715.

Covalent binding affinity to FABP5 at Cys67 residue in human NCI-H358 cells assessed as log2 H/L ratio at 10 uM pretreated for 3 hrs followed by N-(((6S,7R)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepan-6-yl)methyl)-2-hydroxyacetamide treatment for 3 hrs by competitive TMT click chemistry pull-down experiment based LC-MS/MS analysis

Source:: ChEMBL

Protein Target:: Fatty acid-binding protein 5

Assay data:1 Tested

AID:: 1716417

Summary PubMed Citation Related BioAssays by Target

Select item 164840916.

Displacement of 1,8-ANS from recombinant human 6His-tagged FABP5 expressed in Escherichia coli BL21 DE3 incubated for 15 mins followed by 1,8-ANS addition and measured after 3 mins by fluorescence based assay

Source:: ChEMBL

Protein Target:: Fatty acid-binding protein 5

Assay data:10 Active, 6 Activity ≤ 1 µM, 12 Tested

AID:: 1648409

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 162517617.

Displacement of NBD-Stearate from recombinant human FABP5 measured after 30 mins by fluorescence polarization assay

Source:: ChEMBL

Protein Target:: Fatty acid-binding protein 5

Assay data:1 Tested

AID:: 1625176

Summary PubMed Citation Related BioAssays by Target

Select item 160064818.

Displacement of 1,8-ANS from human recombinant full length N-terminal his-tagged FABP5 expressed in Escherichia coli BL21 (DE3) assessed as inhibition of fluorescence at 100 uM incubated for 3 mins by fluorescence based assay relative to control

Source:: ChEMBL

Protein Target:: Fatty acid-binding protein 5

Assay data:2 Tested

AID:: 1600648

Summary PubMed Citation Related BioAssays by Target

Select item 160064219.

Displacement of 1,8-ANS from human recombinant full length N-terminal his-tagged FABP5 expressed in Escherichia coli BL21 (DE3) incubated for 3 mins by fluorescence based assay

Source:: ChEMBL

Protein Target:: Fatty acid-binding protein 5

Assay data:12 Active, 23 Tested

AID:: 1600642

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 160064020.

Displacement of 1,8-ANS from human recombinant full length N-terminal his-tagged FABP5 expressed in Escherichia coli BL21 (DE3) at 25 uM incubated for 3 mins by fluorescence based assay relative to control

Source:: ChEMBL

Protein Target:: Fatty acid-binding protein 5

Assay data:35 Tested

AID:: 1600640

Summary PubMed Citation Related BioAssays by Target

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BioAssays with protein sequences specified as targets
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BioAssays with gene sequences specified as RNAi targets and the activity is active

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BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 µM (15)
BioAssays with the active concentration of tested reagents less than 1 micromolar

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BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
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Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
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Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
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BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

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Literature Extraction (31)
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BioAssays deposited by the NIH Molecular Libraries Program
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