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Inhibition Assay from US Patent US9962362: "Use of small molecule inhibitors targeting EYA tyrosine phosphatase"
Assay data:3 Active, 12 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibitory Assay from US Patent US9725430: "Use of small molecule inhibitors targeting EYA tyrosine phosphatase"
Inhibition of poly-histidine and GST-tagged full length human Eya3 isoform 2 (127 to 573 residues) interaction with His-tagged SIX2 using Ni-NTA agarose gel electrophoresis based pull down assay
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of poly-histidine and GST-tagged full length human Eya3 isoform 2 (127 to 573 residues) assessed as reduction in Km at 5 to 10 uM using para-nitrophenol phosphate substrate incubated for 30 mins
Assay data:1 Active, 1 Tested
Inhibition of poly-histidine and GST-tagged full length human Eya3 isoform 2 (127 to 573 residues) assessed as reduction in Vmax at 5 to 10 uM using para-nitrophenol phosphate substrate incubated for 30 mins
Competitive inhibition of poly-histidine and GST-tagged full length human Eya3 isoform 2 (127 to 573 residues) at 3 to 10 uM using para-nitrophenol phosphate substrate incubated for 30 mins
Inhibition of poly-histidine and GST-tagged full length human Eya3 isoform 2 (127 to 573 residues) using para-nitrophenol phosphate substrate incubated for 30 mins in presence of 0.01% Triton X-100
Inhibition of poly-histidine and GST-tagged full length human Eya3 isoform 2 (127 to 573 residues) using phospho-peptide KKATQASQEpY substrate
Inhibition of poly-histidine and GST-tagged full length human Eya3 isoform 2 (127 to 573 residues) using para-nitrophenol phosphate substrate incubated for 30 mins
Assay data:4 Active, 14 Tested
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Inhibition of human Eya3 isoform 2 (127 to 573 residues) interaction with His-tagged SIX2 at 50 uM by Ni-NTA agarose gel based pull down assay
Non-competitive inhibition of human Eya3 isoform 2 (127 to 573 residues) assessed as reduction in Vmax of substrate incubated for 30 mins by p-nitrophenylphosphate assay
Non-competitive inhibition of human Eya3 isoform 2 (127 to 573 residues) assessed as reduction in Km of substrate incubated for 30 mins by p-nitrophenylphosphate assay
Non-competitive inhibition of human Eya3 isoform 2 (127 to 573 residues) incubated for 30 mins using increasing levels of pNPP substrate
Inhibition of human Eya3 isoform 2 (127 to 573 residues) incubated for 30 mins in presence of 0.01% Triton X-100 by p-nitrophenylphosphate assay
Inhibition of human Eya3 isoform 2 (127 to 573 residues) using KKATOASQEpY phospho-peptide substrate
Inhibition of human Eya3 isoform 2 (127 to 573 residues) incubated for 30 mins by p-nitrophenylphosphate assay
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
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