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KINOMEscan Kinase Assay from US Patent US20240018151: "NOVEL INHIBITORS OF PIKFYVE AND METHODS USING SAME"
Assay data:10 Active, 2 Activity ≤ 1 nM, 10 Activity ≤ 1 µM, 10 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
ADP-GLO Kinase Assay from US Patent US20240018151: "NOVEL INHIBITORS OF PIKFYVE AND METHODS USING SAME"
Assay data:8 Active, 10 Activity ≤ 1 µM, 10 Tested
Biochemical Assay from US Patent US20240016810: "COMPOSITIONS AND METHODS FOR THE TREATMENT AND PREVENTION OF NEUROLOGICAL DISORDERS"
Assay data:21 Active, 1 Activity ≤ 1 nM, 15 Activity ≤ 1 µM, 26 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Kinase Assay from US Patent US11603372: "Compounds and therapeutic uses thereof"
Assay data:19 Active, 8 Activity ≤ 1 nM, 19 Activity ≤ 1 µM, 19 Tested
Affinity Biochemical interaction (Radiometric assay (50 M ATP)) EUB0000014b PIKFYVE
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Affinity Phenotypic Cellular interaction (PtdIns(3;5)P2 production in serum-starved NIH3T3) EUB0000014b PIKFYVE
Inhibition of PIKFYVE (unknown origin)
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human PIKfyve (unknown origin)
Inhibition of human PIKfyve in HEK293 lysate using di-C8 PI(3)P as substrate preincubated for 5 mins followed by substrate addition measured after 2 hrs
Binding affinity to human wild type partial length PIKFYVE (F1512 to C2098 residues) mammalian expression assessed as dissociation constant by Kinomescan method
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of PIKFYVE in HEK293 cells by NanoBRET assay
Assay data:32 Active, 1 Activity ≤ 1 nM, 21 Activity ≤ 1 µM, 34 Tested
Inhibition of human GST tagged PIKFYVE (1493 to end residues) expressed in baculovirus-infected Sf9 cells using PI(3)P:PS as substrate incubated for 60 mins in presence of ATP by ADP-Glo assay
Assay data:22 Active, 1 Activity ≤ 1 nM, 22 Activity ≤ 1 µM, 22 Tested
Inhibition of human wild type partial length PIKfyve (F1512 to C2098 residues) expressed in mammalian expression assessed as remaining activity at 1 uM by Kinomescan assay relative to control
Assay data:32 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human wild type partial length PIKfyve (F1512 to C2098 residues) expressed in mammalian expression system by Kinomescan assay
PIKFYVE DiscoveRx kinase panel
Assay data:1 Tested
SummaryRelated BioAssays by Target
DiscoverX's KINOMEscan Technology Assay from US Patent US11352354: "Substituted penta-fused hexa-heterocyclic compounds, preparation method therefor, drug combination and use thereof"
Assay data:1 Active, 33 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
KinomeScan assay: inhibition of PIKFYVE
Assay data:108 Tested
Inhibition of human PIKFYVE assessed as percent of control at 2000 nM by KINOMEscan assay relative to control
Inhibition of human PIKFYVE assessed as percent of control at 1000 nM by KINOMEscan assay relative to control
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