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Agonist activity at RORgammat in mouse CD4+ T cells assessed as induction of Th17 cells differentiation by measuring increase in IL17 production at 250 nM measured after 4 days by intracellular staining based flow cytometry (Rvb = 16.5 %)
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Agonist activity at RORgammat in mouse CD4+ T cells assessed as induction of Th17 cells differentiation by measuring increase in IL17 production measured after 4 days by intracellular staining based flow cytometry
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
General RORgamma SPA binding assay from US Patent US10273259: "Tricyclic sulfones as RORγ modulators"
Assay data:804 Active, 757 Activity ≤ 1 µM, 804 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Biochemical TR-FRET Assay from US Patent US9745265: "4-heteroaryl substituted benzoic acid compounds as RORgammaT inhibitors and uses thereof"
Assay data:108 Active, 1 Activity ≤ 1 nM, 93 Activity ≤ 1 µM, 126 Tested
Inverse agonist activity at mouse RORC ligand binding domain incubated for 30 mins by scintillation proximity binding assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inverse agonist activity at RORgammat in C57 mouse CD4+ T cells cells assessed as inhibition of Th17 cells differentiation by measuring decrease in IL17 production measured after 4 days by flow cytometry analysis relative to control
Agonist activity at RORgammat in C57 mouse CD4+ T cells cells assessed as induction of Th17 cells differentiation by measuring increase in IL17 production measured after 4 days by flow cytometry analysis relative to control
Assay data:3 Tested
Agonist activity at RORgammat in C57 mouse CD4+ T cells cells assessed as induction of Th17 cells differentiation by measuring increase in IL17 production measured after 4 days by flow cytometry analysis
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
Inverse agonist activity at RORgammat in C57 mouse CD4+ T cells cells assessed as inhibition of Th17 cells differentiation by measuring decrease in IL17 production measured after 4 days by flow cytometry analysis
Inverse agonist activity at RORgammat in mouse Th17 cells assessed as inhibition of CD3/CD28/IL-1/IL-23-induced IL-17A production measured after 24 hrs by AlphaLISA assay
Agonist activity at RORgammat in mouse CD4+ Th17 cells assessed as promotion of IL17 production at 100 nM measured after 4 days by intracellular staining based flow cytometry
Agonist activity at RORgammat in mouse CD4+ Th17 cells assessed as promotion of IL17 production at 300 nM measured after 4 days by intracellular staining based flow cytometry
Assay data:2 Tested
Agonist activity at RORgammat in mouse CD4+ Th17 cells assessed as promotion of IL17 production at 30 nM measured after 4 days by intracellular staining based flow cytometry
Inverse agonist activity at RORgammat in mouse CD4+ T cells assessed as inhibition of differentiation into Th17 cells by measuring IL-17 production at 0.3 uM by flow cytometry relative to control
Inverse agonist activity at RORgammat in mouse CD4+ T cells assessed as inhibition of differentiation into Th17 cells by measuring IL-17 production by flow cytometry relative to control
Inverse agonist activity at RORgammat in mouse CD4+ T cells assessed as inhibition of differentiation into Th17 cells by measuring IL-17 production by flow cytometry
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Inverse agonist activity at RORgammat in mouse Th17 cells
Agonist activity at RORgammat in C57/B6 mouse Th17 cells assessed as increase in IL17F expression after 96 hrs by AlphaLISA
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Agonist activity at RORgammat in C57/B6 mouse Th17 cells assessed as increase in IL17A expression after 96 hrs by AlphaLISA
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
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