BioAssay by Target (List) for Gene (Select 19219) - PubChem BioAssay - NCBI

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Select item 6110961.

Displacement of [3H]-PGE2 from mouse EP4 receptor expressed in CHO cells after 60 mins by liquid scintillation counting

Source:: ChEMBL

Protein Target:: Prostaglandin E2 receptor EP4 subtype

Assay data:4 Active, 11 Tested

AID:: 611096

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 1611882.

Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP4 receptor

Source:: ChEMBL

Protein Target:: Prostaglandin E2 receptor EP4 subtype

Assay data:19 Active, 18 Activity ≤ 1 µM, 19 Tested

AID:: 161188

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 1611893.

Effective concentration for increased intracellular c-AMP production by mouse Prostanoid EP4 receptor

Source:: ChEMBL

Protein Target:: Prostaglandin E2 receptor EP4 subtype

Assay data:13 Active, 13 Activity ≤ 1 µM, 13 Tested

AID:: 161189

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 1611904.

Binding affinity towards mouse Prostanoid EP4 receptor in CHO cells.

Source:: ChEMBL

Protein Target:: Prostaglandin E2 receptor EP4 subtype

Assay data:3 Active, 2 Activity ≤ 1 µM, 17 Tested

AID:: 161190

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 1611915.

Evaluated for its competitive binding affinity towards mouse Prostanoid EP4 receptor in CHO cells expressing prostanoid receptor

Source:: ChEMBL

Protein Target:: Prostaglandin E2 receptor EP4 subtype

Assay data:20 Active, 3 Activity ≤ 1 nM, 20 Activity ≤ 1 µM, 20 Tested

AID:: 161191

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 1611926.

Affinity for mouse Prostanoid EP4 receptor expressed in CHO cells

Source:: ChEMBL

Protein Target:: Prostaglandin E2 receptor EP4 subtype

Assay data:13 Active, 4 Activity ≤ 1 nM, 13 Activity ≤ 1 µM, 13 Tested

AID:: 161192

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 2384047.

Binding affinity for mouse Prostanoid EP4 receptor

Source:: ChEMBL

Protein Target:: Prostaglandin E2 receptor EP4 subtype

Assay data:4 Active, 13 Tested

AID:: 238404

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 2395768.

Ability to inhibit the binding of [3H]PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP4

Source:: ChEMBL

Protein Target:: Prostaglandin E2 receptor EP4 subtype

Assay data:5 Active, 14 Tested

AID:: 239576

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 4546949.

Displacement of [3H]PGE2 from mouse EP4 receptor expressed in CHO cells by liquid scintillation counting

Source:: ChEMBL

Protein Target:: Prostaglandin E2 receptor EP4 subtype

Assay data:13 Active, 2 Activity ≤ 1 µM, 19 Tested

AID:: 454694

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 45992810.

Displacement of [3H]PGE2 from mouse EP4 receptor expressed in CHO cell membrane

Source:: ChEMBL

Protein Target:: Prostaglandin E2 receptor EP4 subtype

Assay data:6 Active, 5 Activity ≤ 1 µM, 6 Tested

AID:: 459928

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 46066911.

Displacement of [3H]PGE3 from mouse EP4 receptor expressed in CHO cells by liquid scintillation counting

Source:: ChEMBL

Protein Target:: Prostaglandin E2 receptor EP4 subtype

Assay data:6 Active, 3 Activity ≤ 1 µM, 7 Tested

AID:: 460669

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 47488212.

Displacement of [3H]PGE2 from mouse EP4 receptor expressed in CHO cells after 60 mins by scintillation counter

Source:: ChEMBL

Protein Target:: Prostaglandin E2 receptor EP4 subtype

Assay data:7 Active, 1 Activity ≤ 1 µM, 10 Tested

AID:: 474882

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 47933713.

Displacement of [3H]PGE2 from mouse EP4 receptor expressed in CHO cells after 60 mins by liquid scintillation counting

Source:: ChEMBL

Protein Target:: Prostaglandin E2 receptor EP4 subtype

Assay data:23 Active, 22 Activity ≤ 1 µM, 23 Tested

AID:: 479337

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 48273914.

Binding affinity to mouse EP4 receptor by competitive binding assay

Source:: ChEMBL

Protein Target:: Prostaglandin E2 receptor EP4 subtype

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 482739

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 48274115.

Agonist activity at mouse EP4 receptor expressed in CHO cells assessed as cAMP production

Source:: ChEMBL

Protein Target:: Prostaglandin E2 receptor EP4 subtype

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 482741

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 191181216.

Antagonist activity at mouse EP4 receptor transfected in CHO/Galpha16 cells preincubated for 15 mins followed by PGE2 addition by calcium flux assay

Source:: ChEMBL

Protein Target:: Prostaglandin E2 receptor EP4 subtype

Assay data:8 Active, 8 Activity ≤ 1 µM, 10 Tested

AID:: 1911812

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 61466217.

Displacement of [3H]PGE2 from mouse prostaglandin EP4 receptor expressed in CHO cells after 60 mins by liquid scintillation counting

Source:: ChEMBL

Protein Target:: Prostaglandin E2 receptor EP4 subtype

Assay data:2 Active, 2 Activity ≤ 1 µM, 11 Tested

AID:: 614662

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 63611218.

Displacement of [3H]-PGE2 from mouse EP4 receptor expressed in CHO cells after 60 mins by liquid scintillation counter

Source:: ChEMBL

Protein Target:: Prostaglandin E2 receptor EP4 subtype

Assay data:27 Active, 10 Activity ≤ 1 nM, 27 Activity ≤ 1 µM, 27 Tested

AID:: 636112

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 63822119.

Displacement of [3H]-PGE2 from mouse EP4 receptor expressed in CHO cells after 60 mins by liquid scintillation counting

Source:: ChEMBL

Protein Target:: Prostaglandin E2 receptor EP4 subtype

Assay data:16 Active, 5 Activity ≤ 1 nM, 16 Activity ≤ 1 µM, 16 Tested

AID:: 638221

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 65086820.

Displacement of [3H]-PGE2 from mouse EP4 receptor expressed in CHO cells after 60 mins by scintillation counting

Source:: ChEMBL

Protein Target:: Prostaglandin E2 receptor EP4 subtype

Assay data:22 Active, 9 Activity ≤ 1 nM, 21 Activity ≤ 1 µM, 22 Tested

AID:: 650868

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

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Target

Proteins (1)
BioAssays with protein sequences specified as targets

BioActivity

Active Compounds (26)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (8)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (23)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (2)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (26)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (1)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (27)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (3)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (2)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (27)
BioAssays extracted from the literature
Other (3)
BioAssays deposited by other experimentalists

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