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Binding Assay from US Patent US9611229: "1,2,3-triazole-4-amine derivatives for the treatment of sigma receptor related diseases and disorders"
Assay data:39 Active, 39 Activity ≤ 1 µM, 39 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Receptor Assay from US Patent US9604926: "Highly selective sigma receptor radioligands"
Assay data:98 Active, 16 Activity ≤ 1 nM, 97 Activity ≤ 1 µM, 99 Tested
Inhibition of radioligand binding to sigma1 receptor in C57BL/6 mouse brain membranes
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Displacement of [3H]-(+)-pentazocin from sigma1 receptor in mouse brain P2 membranes after 240 mins by liquid scintillation counting method
Assay data:1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout
Assay data:762 Active, 16821 Tested
SummaryRelated BioAssays by Same Project
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout
Assay data:1106 Active, 16821 Tested
Displacement of 5-bromo-N-(4-(3,4-dihydro-6,7-dimethoxyisoquinolin-2(1H)-yl)butyl)-2,3-dimethoxybenzamide from sigma-1 receptor in mouse EMT6 cell membranes after 60 mins by Scatchard plot analysis
Assay data:3 Active, 1 Activity ≤ 1 µM, 3 Tested
A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen
Assay data:788 Active, 16789 Tested
SummaryPubMed Citation
Displacement of (+)-[3H]pentazocine from mouse sigma 1 receptor in TRAMP cell membrane
Binding affinity for sigma receptors was evaluated by the inhibitory effect on [3H]DTG to rat whole brain membranes;NT means not tested..
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity for sigma receptors was evaluated by the inhibitory effect on [3H]DTG to rat whole brain membranes;NT means not tested.
Evaluated for the binding affinity at sigma receptor
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Percent inhibition of radioligand [3H]DTG binding to sigma receptor at 10 uM concentration
In vitro binding affinity for the mouse sigma opioid receptor
Assay data:121 Active, 1 Activity ≤ 1 nM, 121 Activity ≤ 1 µM, 122 Tested
Ki value determined against Sigma opioid receptor type 1 using [(+)-[3H]pentazocine at the Kd concentration 2nM
Assay data:11 Active, 7 Activity ≤ 1 µM, 13 Tested
Binding affinity for mouse sigma opioid receptor
Assay data:12 Active, 12 Activity ≤ 1 µM, 13 Tested
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