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Inhibition of IDO2 (unknown origin)
Assay data:2 Active, 5 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human IDO2
Assay data:5 Active, 5 Activity ≤ 1 µM, 24 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of recombinant human IDO2 in HeLa cells at 1 nM relative to control
Assay data:23 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of recombinant human IDO2 in HeLa cells at 100 nM relative to control
Inhibition of IDO2 (unknown origin) assessed as reduction in kynurenine formation using L-tryptophan as substrate by methylene blue reagent based assay relative to control
Assay data:7 Tested
Inhibition of IDO2 (unknown origin) assessed as reduction in kynurenine formation using L-tryptophan as substrate by methylene blue reagent based assay
Assay data:15 Active, 11 Activity ≤ 1 µM, 15 Tested
In-vitro IDO2 Enzyme (Indoleamine 2,3-dioxygenase2) Assay from US Patent US10294212: "Inhibitors of the kynurenine pathway"
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of N-terminal 6His-tagged recombinant human IDO2 (15 to 420 residues) expressed in Escherichia coli using L-Trp as substrate by UV absorbance method
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of IDO2 (unknown origin) expressed in human U87MG cells in presence of L-tryptophan incubated for 24 h
Assay data:5 Active, 1 Activity ≤ 1 µM, 11 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of human IDO2 using L-tryptophan as substrate assessed as reduction in conversion of N-formyl kynurenine to kynurenine
Assay data:3 Active, 11 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of human IDO2 at 10 uM using L-tryptophan as substrate incubated for 30 min assessed as reduction in conversion of N-formyl kynurenine to kynurenine relative to control
Assay data:11 Tested
SummaryRelated BioAssays by Target
Noncompetitive inhibition of human IDO2 using L-tryptophan as substrate incubated for 30 min assessed as reduction in conversion of N-formyl kynurenine to kynurenine by dixon plot analysis
Assay data:1 Tested
Mixed competitive inhibition of human IDO2 using L-tryptophan as substrate incubated for 30 min assessed as reduction in conversion of N-formyl kynurenine to kynurenine by dixon plot analysis
Uncompetitive inhibition of human IDO2 using L-tryptophan as substrate incubated for 30 min assessed as reduction in conversion of N-formyl kynurenine to kynurenine by dixon plot analysis
Assay data:3 Active, 1 Activity ≤ 1 µM, 7 Tested
Competitive inhibition of human IDO2 using L-tryptophan as substrate incubated for 30 min assessed as reduction in conversion of N-formyl kynurenine to kynurenine by dixon plot analysis
Assay data:2 Tested
Inhibition of human IDO2 expressed in Escherichia coli BL21 Star assessed as kynurenine formation using L-Trp as substrate preincubated for 90 mins measured after 30 mins by bridge-IT fluorescence assay
Inhibition of N-terminal His-tagged human IDO2 expressed in Escherichia coli expression system
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Binding affinity to human IDO2 at 200 uM by STD NMR spectrometry analysis
Assay data:1 Active, 2 Tested
Binding affinity to human IDO2 assessed as change in spectral signal at 200 uM by CPMG NMR spectrometry analysis
Noncompetitive inhibition of C-terminal His6-tagged human IDO2 (14 to 420 residues) expressed in Escherichia coli BL21 (DE3) assessed as inhibition constant using varying concentration of L-tryptophan as substrate by Dixon plot analysis
Assay data:3 Tested
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