BioAssay by Target (List) for Gene (Select 1645) - PubChem BioAssay - NCBI

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Select item 5368071.

Inhibition of human AKR1C1-mediated progesterone metabolism expressed in bovine aortic endothelial cells assessed as formation of 20alpha-hydroxyprogesterone pretreated for 2 hrs before progesterone challenge measured after 6 hrs by LC/MS analysis

Source:: ChEMBL

Protein Target:: Aldo-keto reductase family 1 member C1

Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested

AID:: 536807

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 5014842.

Ratio of kcat/km for human recombinant AKR1C1 Leu308Val mutant expressed in Escherichia coli JM109 after 15 mins

Source:: ChEMBL

Protein Target:: Aldo-keto reductase family 1 member C1

Assay data:3 Tested

AID:: 501484

Summary PubMed Citation Related BioAssays by Target

Select item 5014853.

Ratio of Km for human recombinant AKR1C1 Leu308Val mutant to Km for human recombinant wild type AKR1C1

Source:: ChEMBL

Protein Target:: Aldo-keto reductase family 1 member C1

Assay data:3 Tested

AID:: 501485

Summary PubMed Citation Related BioAssays by Target

Select item 5014864.

Activity at human recombinant AKR1C1 Leu308Ala mutant expressed in Escherichia coli JM109 after 15 mins

Source:: ChEMBL

Protein Target:: Aldo-keto reductase family 1 member C1

Assay data:1 Tested

AID:: 501486

Summary PubMed Citation Related BioAssays by Target

Select item 5014875.

Ratio of kcat/km for human recombinant AKR1C1 Leu308Ala mutant expressed in Escherichia coli JM109 after 15 mins

Source:: ChEMBL

Protein Target:: Aldo-keto reductase family 1 member C1

Assay data:1 Tested

AID:: 501487

Summary PubMed Citation Related BioAssays by Target

Select item 5014886.

Ratio of Km for human recombinant AKR1C1 Leu308Ala mutant to Km for human recombinant wild type AKR1C1

Source:: ChEMBL

Protein Target:: Aldo-keto reductase family 1 member C1

Assay data:1 Tested

AID:: 501488

Summary PubMed Citation Related BioAssays by Target

Select item 5014897.

Ratio of Kcat/Km for human recombinant AKR1C1 Leu308Val mutant to Kcat/Km for human recombinant wild type AKR1C1

Source:: ChEMBL

Protein Target:: Aldo-keto reductase family 1 member C1

Assay data:3 Tested

AID:: 501489

Summary PubMed Citation Related BioAssays by Target

Select item 5014908.

Ratio of Kcat/Km for human recombinant AKR1C1 Leu308Ala mutant to Kcat/Km for human recombinant wild type AKR1C1

Source:: ChEMBL

Protein Target:: Aldo-keto reductase family 1 member C1

Assay data:1 Tested

AID:: 501490

Summary PubMed Citation Related BioAssays by Target

Select item 5367989.

Inhibition of human wild type AKR1C1 dehydrogenase activity by fluorometric assay

Source:: ChEMBL

Protein Target:: Aldo-keto reductase family 1 member C1

Assay data:12 Active, 1 Activity ≤ 1 nM, 12 Activity ≤ 1 µM, 12 Tested

AID:: 536798

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 53679910.

Inhibition of human AKR1C1 Leu308Val mutant dehydrogenase activity by fluorometric assay

Source:: ChEMBL

Protein Target:: Aldo-keto reductase family 1 member C1

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 536799

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 53680011.

Inhibition of human AKR1C1 Leu308Ala mutant dehydrogenase activity by fluorometric assay

Source:: ChEMBL

Protein Target:: Aldo-keto reductase family 1 member C1

Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested

AID:: 536800

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 53680512.

Inhibition of human AKR1C1-mediated progesterone metabolism expressed in bovine aortic endothelial cells assessed as formation of 20alpha-hydroxyprogesterone at 2 uM pretreated for 2 hrs before progesterone challenge measured after 6 hrs by LC/MS analysis

Source:: ChEMBL

Protein Target:: Aldo-keto reductase family 1 member C1

Assay data:1 Tested

AID:: 536805

Summary PubMed Citation Related BioAssays by Target

Select item 53680613.

Inhibition of human AKR1C1-mediated progesterone metabolism expressed in bovine aortic endothelial cells assessed as formation of 20alpha-hydroxyprogesterone at 0.01 uM pretreated for 2 hrs before progesterone challenge measured after 6 hrs by LC/MS analysis

Source:: ChEMBL

Protein Target:: Aldo-keto reductase family 1 member C1

Assay data:1 Tested

AID:: 536806

Summary PubMed Citation Related BioAssays by Target

Select item 50148314.

Activity at human recombinant AKR1C1 Leu308Val mutant expressed in Escherichia coli JM109 after 15 mins

Source:: ChEMBL

Protein Target:: Aldo-keto reductase family 1 member C1

Assay data:3 Tested

AID:: 501483

Summary PubMed Citation Related BioAssays by Target

Select item 59100415.

Competitive inhibition of human recombinant AKR1C1 Leu54Val mutant by fluorescence assay

Source:: ChEMBL

Protein Target:: Aldo-keto reductase family 1 member C1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 591004

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 59100516.

Competitive inhibition of human recombinant AKR1C1 Leu306Ala mutant by fluorescence assay

Source:: ChEMBL

Protein Target:: Aldo-keto reductase family 1 member C1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 591005

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 59100617.

Binding affinity to human AKR1C1 after 4 hrs by crystallography

Source:: ChEMBL

Protein Target:: Aldo-keto reductase family 1 member C1

Assay data:2 Active, 2 Tested

AID:: 591006

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 59100718.

Competitive inhibition of human recombinant AKR1C1 Leu308Val mutant by fluorescence assay

Source:: ChEMBL

Protein Target:: Aldo-keto reductase family 1 member C1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 591007

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 59100819.

Competitive inhibition of human recombinant AKR1C1 Leu308Ala mutant by fluorescence assay

Source:: ChEMBL

Protein Target:: Aldo-keto reductase family 1 member C1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 591008

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 59100920.

Competitive inhibition of human recombinant AKR1C1 Phe311Leu mutant by fluorescence assay

Source:: ChEMBL

Protein Target:: Aldo-keto reductase family 1 member C1

Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested

AID:: 591009

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

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Target

RNAi Target, Active (5)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (42)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (3)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (26)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (49)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (7)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (89)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (11)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (1)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (89)
BioAssays extracted from the literature
Other (11)
BioAssays deposited by other experimentalists

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