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Inhibition of CYP450 (unknown origin)
Assay data:14 Active, 16 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Drug metabolism in human liver S9 fractions assessed as CYP450-mediated phase 1 metabolism at 1 mM preincubated for 5 mins followed by NADPH addition and measured after 60 mins by RP-UHPLC-DAD analysis relative to control
Assay data:3 Tested
SummaryPubMed CitationRelated BioAssays by Target
Drug metabolism in human hepatocytes assessed as CYP450-mediated phase-2 glucuronidation/oxidation at 4 uM measured after 120 mins by LC-MS/MS analysis
Assay data:1 Tested
Drug metabolism in human hepatocytes assessed as CYP450-mediated phase-2 glucuronidation/ketone reduction at 4 uM measured after 120 mins by LC-MS/MS analysis
Drug metabolism in human hepatocytes assessed as CYP450-mediated oxidation at 4 uM measured after 120 mins by LC-MS/MS analysis
Induction of CYP450 in human liver microsomes at 10 uM after 0.5 hrs by LC-MS/MS analysis
Inhibition of CYP450 in human liver microsomes at 10 uM after 0.5 hrs by LC-MS/MS analysis
Half life in human liver microsomes assessed as CYP450-mediated compound degradation at 10 uM by UV-HPLC analysis
Drug metabolism in human liver microsome S9 fraction assessed as CYP450-mediated metabolism by measuring compound remaining at 5 uM pretreated with NADPH and measured after 60 mins by UPLC-MS/MS analysis
Assay data:1 Active, 4 Tested
Drug metabolism in human liver microsome S9 fraction assessed as CYP450-mediated metabolism by measuring compound remaining at 5 uM pretreated with NADPH and measured after 30 mins by UPLC-MS/MS analysis
Drug metabolism in human liver microsome S9 fraction assessed as CYP450-mediated metabolism by measuring compound remaining at 5 uM pretreated with NADPH and measured after 15 mins by UPLC-MS/MS analysis
Inhibition of human CYP450 (unknown origin)
Induction of CYP450 (unknown origin)
Assay data:2 Tested
Microsomal stability in human liver microsomes assessed as CYP450-mediated metabolism by measuring compound remaining at 5 uM and measured for 60 mins in presence of NADPH by UPLC-MS/MS analysis (Rvb = 100%)
Assay data:7 Tested
Microsomal stability in human liver microsomes assessed as CYP450-mediated metabolism by measuring compound remaining at 5 uM and measured for 30 mins in presence of NADPH by UPLC-MS/MS analysis (Rvb = 100%)
Microsomal stability in human liver microsomes assessed as CYP450-mediated metabolism by measuring compound remaining at 5 uM and measured for 15 mins in presence of NADPH by UPLC-MS/MS analysis (Rvb = 100%)
Drug metabolism in human hepatocytes assessed as cytochrome P450-mediated oxidation on bicyclo[4.1.0]heptane formation incubated for 120 mins by LC-QTOFMS analysis
Drug metabolism in human hepatocytes assessed as cytochrome P450-mediated 4-((1S,3R,4R,6R)-4-(6-(5-(hydroxymethyl)-1H-pyrazol-3-yl)benzo[d]isoxazol-3-yl)bicyclo[4.1.0]heptane-3-carboxamido)-1-methyl-1H-pyrazole-3-carboxamide formation incubated for 120 mins by LC-QTOFMS analysis
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