Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
Activity of human recombinant CYP2A6 expressed in microsomes isolated from human AHH-1 cells assessed as enzyme-mediated 3-(2,4-dimethylphenylthio)-4-(piperazin-1-yl)phenol formation at 8 to 50 uM after 120 mins by HPLC/MS-MS analysis in presence of NADPH regenerating system with NADP+
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Drug metabolism in human liver microsomes assessed as monoclonal antibody-mediated inhibition of CYP2A6-mediated (R)-1-(4-(4-fluoro-2-(hydroxymethyl)-1H-indol-5-yloxy)-5-methylpyrrolo[1,2-f][1,2,4]triazin-6-yloxy)propan-2-ol formation at 2 and 20 uM for 30 mins by LC/MS analysis
Activity of human CYP2A6 assessed as compound formation treated with 2 and 20 uM brivanib for 20 mins by LC/MS analysis in presence of NADPH
Drug metabolism in human liver microsomes assessed as 2 uM tranylcypromine-mediated inhibition of CYP2A6-mediated (R)-1-(4-(4-fluoro-2-(hydroxymethyl)-1H-indol-5-yloxy)-5-methylpyrrolo[1,2-f][1,2,4]triazin-6-yloxy)propan-2-ol formation at 2 and 20 uM for 30 mins by LC/MS analysis
Drug metabolism assessed as human CYP2A6-mediated (R)-1-(4-(4-fluoro-2-(hydroxymethyl)-1H-indol-5-yloxy)-5-methylpyrrolo[1,2-f][1,2,4]triazin-6-yloxy)propan-2-ol formation at 2 and 20 uM for 20 mins by LC/MS analysis in presence of NADPH
Inhibition of CYP2A6 in human liver microsomes assessed as coumarin 7-hydroxylation after 3 mins by LC-MS/MS analysis in presence of NADPH
Assay data:2 Tested
Inhibition of CYP2A6 in human liver microsomes assessed as coumarin 7-hydroxylation preincubated for 15 mins by LC-MS/MS analysis in presence of NADPH
Drug metabolism in human recombinant CYP2A6 mediated oxidative metabolism at 10 uM
Drug metabolism in human liver microsomes assessed as CYP2A6-mediated nicotinamide N-oxide formation by HPLC analysis
Drug level in human recombinant CYP2A6 expressed in insect cells coexpressing NADPH-P450 reductase measured per pmol of enzyme treated with 100 uM cinobufagin at 37 degC after 30 mins by UFLC-DAD-ESI-MS analysis
Activity of recombinant human CYP2A6 expressed in microsomes isolated from baculovirus infected insect cell assessed as enzyme-mediated compound depletion at 0.02 uM after 30 mins by LC-MS analysis
Activity of recombinant human CYP2A6 expressed in microsomes isolated from baculovirus infected insect cell assessed as enzyme-mediated metabolite formation at 10 uM after 60 mins by LC-MS analysis
Activity of recombinant human CYP2A6 expressed in microsomes isolated from baculovirus infected insect cell assessed as enzyme-mediated 2-(2-((R)-3-((1-(carboxymethyl)cyclopropyl)methylthio)-3-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)propyl)phenyl)-2-hydroxypropanoic acid formation at 1 uM after 30 mins by LC-MS analysis
Activity of human recombinant CYP2A6 assessed as enzyme-mediated 2-hydroxyethyl (1R,3aR,4aR,6R,8aR,9S,9aS)-9-((E)-2-(5-(3-fluorophenyl)pyridin-2-yl)vinyl)-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-ylcarbamate formation at 25 uM after 120 mins by LC-MS/MS analysis in presence of NADPH
Activity of human recombinant CYP2A6 expressed in microsomes isolated from human AHH-1 cells assessed as enzyme-mediated 1-(2-(2,4-dimethylphenylsulfinyl)phenyl)piperazine formation at 8 to 50 uM after 120 mins by HPLC/MS-MS analysis in presence of NADPH regenerating system with NADP+
Activity of human recombinant CYP2A6 expressed in microsomes isolated from human AHH-1 cells assessed as enzyme-mediated compound formation treated with Lu AA21004 at 8 to 50 uM after 120 mins by HPLC/MS-MS analysis in presence of NADPH regenerating system with NADP+
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
Inhibition of human microsomal CYP2A6
Assay data:15 Active, 1 Activity ≤ 1 nM, 15 Activity ≤ 1 µM, 15 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of CYP2A6 in human liver microsomes using coumarin as substrate preincubated with substrate for 5 mins followed by NADPH addition measured after 20 mins by HPLC analysis
Drug metabolism assessed as recombinant human CYP2A6 mediated metabolite formation at 10 uM preincubated for 5 mins followed by addition of NADPH measured after 120 mins by HPLC-TIC chromatography
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on