BioAssay by Target (List) for Gene (Select 151306) - PubChem BioAssay - NCBI

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Select item 19548441.

Activation of TGR5 (unknown origin) at 10 uM

Source:: ChEMBL

Protein Target:: G-protein coupled bile acid receptor 1

Assay data:1 Tested

AID:: 1954844

Summary PubMed Citation Related BioAssays by Target

Select item 19493592.

Agonist activity at GPBAR1 in human NCI-H716 cells

Source:: ChEMBL

Protein Target:: G-protein coupled bile acid receptor 1

Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested

AID:: 1949359

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19440373.

Agonist activity at human TGR5

Source:: ChEMBL

Protein Target:: G-protein coupled bile acid receptor 1

Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested

AID:: 1944037

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19440354.

Agonist activity at human TGR5 relative to LCA

Source:: ChEMBL

Protein Target:: G-protein coupled bile acid receptor 1

Assay data:1 Tested

AID:: 1944035

Summary PubMed Citation Related BioAssays by Target

Select item 19440315.

Agonist activity at human TGR5 in human NCI-H716 cells assessed as stimulation of GLP-1 secretion incubated for 2 hrs by ELISA analysis relative to control

Source:: ChEMBL

Protein Target:: G-protein coupled bile acid receptor 1

Assay data:1 Tested

AID:: 1944031

Summary PubMed Citation Related BioAssays by Target

Select item 19440306.

Agonist activity at human TGR5 expressed in human HEK293 cells at 20 uM measured after 5.5 hrs by steady-glo luciferase assay relative to control

Source:: ChEMBL

Protein Target:: G-protein coupled bile acid receptor 1

Assay data:4 Tested

AID:: 1944030

Summary PubMed Citation Related BioAssays by Target

Select item 19440297.

Agonist activity at human TGR5 expressed in human HEK293 cells measured after 5.5 hrs by steady-glo luciferase assay

Source:: ChEMBL

Protein Target:: G-protein coupled bile acid receptor 1

Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested

AID:: 1944029

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19440288.

Agonist activity at TGR5 in human HEK293 cells assessed as increase in cAMP production

Source:: ChEMBL

Protein Target:: G-protein coupled bile acid receptor 1

Assay data:14 Active, 2 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 14 Tested

AID:: 1944028

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19440249.

Agonist activity at human TGR5 transfected in CHO cells assessed as increase in cAMP production at 1 uM relative to control

Source:: ChEMBL

Protein Target:: G-protein coupled bile acid receptor 1

Assay data:1 Tested

AID:: 1944024

Summary PubMed Citation Related BioAssays by Target

Select item 194402310.

Agonist activity at human TGR5 transfected in human NCI-H716 cells assessed as increase in cAMP production at 10 uM relative to control

Source:: ChEMBL

Protein Target:: G-protein coupled bile acid receptor 1

Assay data:1 Tested

AID:: 1944023

Summary PubMed Citation Related BioAssays by Target

Select item 194402211.

Agonist activity at human TGR5 transfected in human NCI-H716 cells assessed as increase in GLP-1 secretion at 5 uM relative to control

Source:: ChEMBL

Protein Target:: G-protein coupled bile acid receptor 1

Assay data:1 Tested

AID:: 1944022

Summary PubMed Citation Related BioAssays by Target

Select item 194402012.

Agonist activity at human TGR5 transfected in CHO cells assessed as increase in cAMP production

Source:: ChEMBL

Protein Target:: G-protein coupled bile acid receptor 1

Assay data:7 Active, 1 Activity ≤ 1 nM, 7 Activity ≤ 1 µM, 7 Tested

AID:: 1944020

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 194401913.

Agonist activity at TGR5 in human HEK293 cells incubated for 30 mins

Source:: ChEMBL

Protein Target:: G-protein coupled bile acid receptor 1

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1944019

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 194401814.

Agonist activity at TGR5 in human STC1 cells assessed as increase in GLP-1 secretion

Source:: ChEMBL

Protein Target:: G-protein coupled bile acid receptor 1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1944018

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 194401615.

Agonist activity at human TGR5 transfected in CHO-K1 cells assessed as increase in cAMP production

Source:: ChEMBL

Protein Target:: G-protein coupled bile acid receptor 1

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1944016

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 194401516.

Agonist activity at TGR5 in human T-lymphocyte cells assessed as increase in cAMP production

Source:: ChEMBL

Protein Target:: G-protein coupled bile acid receptor 1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1944015

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 194401417.

Agonist activity at human TGR5 transfected in CHO cells assessed as increase in cAMP production at 100 nM relative to control

Source:: ChEMBL

Protein Target:: G-protein coupled bile acid receptor 1

Assay data:3 Tested

AID:: 1944014

Summary PubMed Citation Related BioAssays by Target

Select item 194401218.

Agonist activity at human TGR5 transfected in human NCI-H716 cells assessed as fold increase in GLP-1 secretion

Source:: ChEMBL

Protein Target:: G-protein coupled bile acid receptor 1

Assay data:1 Tested

AID:: 1944012

Summary PubMed Citation Related BioAssays by Target

Select item 194400419.

Agonist activity at TGR5 (unknown origin)

Source:: ChEMBL

Protein Target:: G-protein coupled bile acid receptor 1

Assay data:1 Active, 1 Tested

AID:: 1944004

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 193292720.

Agonist activity at TGR5 (unknown origin) expressed in CHO cells incubated for 0.5 hr by microplate reader based analysis

Source:: ChEMBL

Protein Target:: G-protein coupled bile acid receptor 1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1932927

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

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Target

Proteins (1)
BioAssays with protein sequences specified as targets
RNAi Target, Active (6)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (92)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (11)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (63)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (2)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (76)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (9)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (186)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (14)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (2)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (185)
BioAssays extracted from the literature
NIH MLP (1)
BioAssays deposited by the NIH Molecular Libraries Program
Other (14)
BioAssays deposited by other experimentalists

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BioAssay by Target (List) for Gene (Select 151306) (200)
PubChem BioAssay
Homo sapiens G protein-coupled bile acid receptor 1 (GPBAR1), transcript variant...
Homo sapiens G protein-coupled bile acid receptor 1 (GPBAR1), transcript variant 2, mRNA
gi|1675114924|ref|NM_001077194.2|

Nucleotide

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