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Selectivity interaction (KinomeScan (DiscoverX)) EUB0000549a TRPM6
Assay data:1 Tested
SummaryRelated BioAssays by Target
TRPM6 DiscoveRx kinase panel
KinomeScan assay: inhibition of TRPM6
Assay data:1 Active, 108 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of human TRPM6 assessed as percent of control at 2000 nM by KINOMEscan assay relative to control
Inhibition of DNA-tagged human TRPM6 assessed as percent of control at 50000 nM by qPCR analysis relative to control
Inhibition of human TRPM6 assessed as percent of control at 1000 nM by KINOMEscan assay relative to control
Binding affinity to wild-type human partial length TRPM6 (Q1723 to I1998 residues) expressed in mammalian expression system assessed as residual binding level at 10 uM by Kinomescan method relative to control
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of wild-type human partial length TRPM6 (Q1723 to I1998 residues) expressed in mammalian expression system at 1 uM by Kinomescan method relative to control
Inhibition of wild-type human partial length TRPM6 (Q1723 to I1998 residues) expressed in mammalian expression system at 10 uM by Kinomescan method relative to control
Binding affinity to wild-type human partial length TRPM6 (Q1723 to I1998 residues) expressed in mammalian expression system assessed as residual binding level at 1 uM by Kinomescan method relative to control
Inhibition of wild-type human partial length TRPM6 (Q1723 to I1998 residues) expressed in mammalian expression system assessed as residual activity at 10 uM by Kinomescan method relative to control
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Inhibition of wild-type human partial length TRPM6 (Q1723 to I1998 residues) expressed in mammalian expression system assessed as residual activity at 50 nM by Kinomescan method relative to control
Assay data:2 Tested
Inhibition of wild-type human partial length TRPM6 (Q1723 to I1998 residues) expressed in mammalian expression system assessed as residual activity at 1 uM by Kinomescan method relative to control
Inhibition of wild-type human partial length TRPM6 (Q1723 to I1998 residues) expressed in HEK293 cells assessed as residual activity at 1000 nM after 30 mins by Kinomescan method relative to control
Binding affinity to wild-type human partial length TRPM6 (Q1723 to I1998 residues) expressed in mammalian expression system assessed as remaining unbound target protein level at 1000 nM by Kinomescan method relative to control
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