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Inhibition of carboxypeptidase A (unknown origin) assessed as reduction in hydrolysis of hippuryl-L-phenylalanine using hippuryl-L-phenylalanine as substrate
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of carboxypeptidase A (unknown origin)
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of carboxypeptidase A (unknown origin) assessed as reduction in degradation of N-(4-methoxyphenylazoformyl)-Phe-OH at > 10 uM using N-(4-methoxyphenylazoformyl)-Phe-OH as substrate
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of carboxypeptidase A (unknown origin) assessed as reduction in degradation of N-(4-methoxyphenylazoformyl)-Phe-OH using N-(4-methoxyphenylazoformyl)-Phe-OH as substrate
Assay data:1 Active, 5 Tested
Inhibition of human CPA1 peptide degradation activity at 5 to 500 nM using neurotensin peptide as substrate preincubated for 2 hrs followed by substrate addition and measured up to 7 hrs by MALDI-TOF/TOF spectrometry
Inhibition of human CPA1 using AAFP as substrate measured at pre-steady state by spectrophotometry
Assay data:4 Active, 4 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
Inhibition of human CPA1 using AAFP as substrate assessed as association rate constant measured at pre-steady state by spectrophotometry
Assay data:4 Tested
Inhibition of human CPA1 using AAFP as substrate assessed as apparent first-order rate constant measured at pre-steady state by measuring Koff/Kon ratio by spectrophotometry
Inhibition of human CPA1 using AAFP as substrate assessed as dissociation rate constant measured at pre-steady state by spectrophotometry
Inhibition of human CPA1 using AAFP as substrate preincubated for 45 mins to 2 hrs measured at 30 sec intervals for 15 mins by UV/vis-spectrophotometry
Assay data:11 Active, 7 Activity ≤ 1 nM, 11 Activity ≤ 1 µM, 11 Tested
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
RNAi screen for vemurafenib enhancers in BRAFV600 melanoma - Secondary Screen
Assay data:623 Active, 1600 Tested
Irreversible inhibition of recombinant human carboxypeptidase A1 expressed in Pichia pastoris using N-(4-methoxyphenylazoformyl)-Phe-OH as substrate measured for 600 secs by double reciprocal plot analysis
Assay data:6 Tested
Human Carboxypeptidase A1 (pancreatic) (M14: Carboxypeptidase A)
Stability of the compound in Tris buffer assessed as carboxypeptidase A (unknown origin)-mediated compound degradation by measuring intact compound level at pH 7.5 at 37 degC after 6 hrs by UPLC analysis
Stability of the compound in Tris buffer assessed as carboxypeptidase A (unknown origin)-mediated compound degradation at pH 7.5 at 37 degC after 4 hrs by UPLC analysis
Assay data:2 Tested
Inhibition of CPA (unknown origin)
Assay data:2 Active, 4 Tested
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
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