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Kinase Inhibition Assay from Article 10.1021/jm050267e: "1-Acyl-1H-[1,2,4]triazole-3,5-diamine analogues as novel and potent anticancer cyclin-dependent kinase inhibitors: synthesis and evaluation of biological activities."
Assay data:15 Active, 3 Activity ≤ 1 nM, 14 Activity ≤ 1 µM, 16 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of Cdk4 in mouse C2C12 cells assessed as reduction in phospho-sites occupancy at 4 uM after 5 hrs by SILAC based LC-MS/MS analysis relative to control
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Protac activity at CRBN/CDK4 in mouse B16F10 cells assessed as induction of CDK4 protein degradation at 100 nM for 6 hrsin presence of Ribociclib by Western blot analysis
Assay data:1 Tested
Protac activity at CRBN/CDK4 in mouse B16F10 cells assessed as induction of CDK4 protein degradation at 100 nM for 6 hrsin presence of methyl 6-(7-cyclopentyl-6-(dimethylcarbamoyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)nicotinate by Western blot analysis
Protac activity at CRBN/CDK4 in mouse B16F10 cells assessed as induction of CDK4 protein degradation at 100 nM for 6 hrsin presence of Pomalidomide by Western blot analysis
Protac activity at CRBN/CDK4 in mouse B16F10 cells assessed as induction of CDK4 protein degradation at 100 nM for 6 hrs in presence of proteasome inhibitor MG132 by Western blot analysis
Protac activity at CRBN/CDK4 in mouse B16F10 cells assessed as induction of CDK4 protein degradation at 500 nM by Western blot analysis
Protac activity at CRBN/CDK4 in mouse B16F10 cells assessed as induction of CDK4 protein degradation after 12 hrs by Western blot analysis
Inhibition of CDK2/4 in mouse 4T1 cells assessed as decrease in phosphorylation of Rb at 0.78 to 3.125 uM after 24 hrs by Western blot method
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout
Assay data:762 Active, 16821 Tested
SummaryRelated BioAssays by Same Project
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout
Assay data:1106 Active, 16821 Tested
A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen
Assay data:788 Active, 16789 Tested
SummaryPubMed Citation
Inhibition of CDK4 at 10 ug/mL
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