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Inhibition of CCR8 mutant (unknown origin)
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Antagonist activity against CCR8 (unknown origin) assessed as inhibition of beta-arrestin 2 recruitment at 10 microM by beta arrestin assay relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Agonist activity against CCR8 (unknown origin) assessed as induction of beta-arrestin 2 recruitment at 10 microM by beta arrestin assay relative to control
PRESTO-Tango GPCRome screening (CCR8)
SummaryRelated BioAssays by Target
Agonist activity at human CCR8 expressed in CHO-K1 cells at 20 uM by PathHunter beta-arrestin assay relative to control
Assay data:8 Tested
Antagonist activity at human CCR8 expressed in CHO-K1 cells by PathHunter beta-arrestin assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Antagonist activity at human CCR8 expressed in CHO-K1 cells at 20 uM by PathHunter beta-arrestin assay relative to control
Antagonist activity at human CCR8 receptor assessed as inhibition of CCL1-induced beta arrestin2 recruitment at 500 nM preincubated for 30 mins followed by CCL1 stimulation and measured after 90 to 180 mins by pathhunter assay
Antagonist activity at human CCR8 expressed in CHOK1 cells assessed as reduction in CCL1-induced beta-arrestin 2 recruitment incubated for 30 mins followed by CCL1 addition and measured after 90 or 180 mins by pathhunter beta-arrestin assay
Antagonist activity at human CCR8 expressed in CHOK1 cells assessed as inhibition in CCL1-induced beta-arrestin 2 recruitment at 20 uM incubated for 30 mins followed by CCL1 addition and measured after 90 or 180 mins by pathhunter beta-arrestin assay relative to control
Assay data:9 Tested
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Antagonist activity at CCR8 (unknown origin) at 10 uM
Assay data:3 Tested
Antagonist activity at CCR8 (unknown origin)
Agonist activity at CCR8 (unknown origin)
Human CCR8 (Chemokine receptors)
Assay data:6 Active, 6 Tested
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
InfectX: Pathogen infection siRNA screens
Assay data:115372 Tested
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