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Drug metabolism assessed as mouse AChE-mediated hydrolysis by measuring 6-(1-(dimethylamino) ethyl) quinolin-8-ol incubated for 12 hrs by HPLC analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Drug metabolism assessed as mouse AChE-mediated hydrolysis by measuring 6-(1-(dimethylamino) ethyl) quinolin-8-ol incubated for 48 hrs by HPLC analysis
Antagonist activity at mouse alpha1beta1epcilondelta nACHR expressed in xenopous laevis oocyte assessed as inhibition of ACh induced channel current after 5 mins at -70 mV holding potential by two electrode voltage clamp method
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout
Assay data:762 Active, 16821 Tested
SummaryRelated BioAssays by Same Project
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout
Assay data:1106 Active, 16821 Tested
Inhibition of mouse alpha1beta1deltaepsilon nAChR expressed in Xenopus laevis oocytes assessed as inhibition of ACh-induced current after 2 to 4 days by voltage clamp electrophysiology method
Agonist activity at mouse alpha1beta1epsilondelta nAChR expressed in Xenopus laevis oocytes at 1 uM incubated for 8 secs followed by compound washout for 241 secs by Two-electrode voltage clamp assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Antagonist activity at mouse alpha1beta1epsilondelta nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced effect at 10 uM incubated for 8 secs followed by compound washout for 241 secs by Two-electrode voltage clamp assay
Agonist activity at mouse alpha1beta1epsilondelta nAChR expressed in Xenopus laevis oocytes at 10 uM incubated for 8 secs followed by compound washout for 241 secs by Two-electrode voltage clamp assay
Assay data:3 Tested
Antagonist activity at mouse muscle alpha1beta1epsilondelta nAChR expressed in Xenopus oocytes assessed as inhibition of acetylcholine-induced effect at 1 uM incubated for 8 secs followed by compound washout measured after 241 secs by two-electrode voltage clamp technique
Assay data:1 Active, 25 Tested
Agonist activity at mouse muscle alpha1beta1epsilondelta nAChR expressed in Xenopus oocytes at 1 uM incubated for 8 secs followed by compound washout measured after 241 secs by two-electrode voltage clamp technique
Assay data:15 Tested
Agonist activity at mouse muscle alpha1beta1epsilondelta nAChR expressed in Xenopus oocytes at 10 uM incubated for 8 secs followed by compound washout measured after 241 secs by two-electrode voltage clamp technique
Assay data:24 Tested
A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen
Assay data:788 Active, 16789 Tested
SummaryPubMed Citation
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