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Inhibitory concentration against Nicotinic acetylcholine receptor alpha-6-alpha-3-beta-2-beta-3; Range is 0.7-1 nM
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at human alpha6/alpha3beta2beta3 nAChR expressed in human SHEP1 cells assessed as stimulation of 86Rb+ ion efflux after 5 mins by liquid scintillation counting analysis relative to carbamylcholine
Assay data:5 Tested
SummaryPubMed CitationRelated BioAssays by Target
Antagonist activity at human alpha6/alpha3beta2beta3 nAChR expressed in human SHEP1 cells assessed as inhibition of carbamylcholine-induced 86Rb+ ion efflux preincubated for 10 mins by liquid scintillation counting analysis
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
Antagonist activity at human alpha6/alpha3beta2beta3 nAChR expressed in human SHEP1 cells assessed as inhibition of carbamylcholine-induced 86Rb+ ion efflux preincubated for 10 mins by liquid scintillation counting analysis relative to control
RNAi screen for vorinostat resistance genes - Primary Screen
Assay data:450 Active, 18118 Tested
SummaryPubMed Citation
Druggable Genome siRNA Screen for Enhancers of Camptothecin in MDA-MB-231 Breast Cancer Cells
Assay data:167 Active, 26449 Tested
Summary
Displacement of [125I]epibatidine from human alpha6/alpha3beta2beta3 nAChR expressed in HEK293T cells
Assay data:7 Active, 2 Activity ≤ 1 nM, 7 Activity ≤ 1 µM, 7 Tested
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Ambion Library)
Assay data:9227 Active, 64752 Tested
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Dharmacon Library)
Assay data:826 Active, 18119 Tested
An siRNA screen for human genes that are involved in human papilloma virus (HPV) E2 transcriptional repression of the E6 and E7 oncogenes
Assay data:497 Active, 21019 Tested
Agonist activity at human alpha6/alpha3beta2beta3 nAChR expressed in human SHEP1 cells assessed as stimulation of 86Rb+ ion efflux after 5 mins by liquid scintillation counting analysis
Stimulation of cation efflux in human nAChR subtype alpha3-betaX expressing IMR-32 cells
Assay data:1 Tested
Maximal efficacy relative to 100 uM nicotine in Nicotinic acetylcholine receptor alpha3-betaX subtype expressing IMR-32 cells
Assay data:2 Tested
Stimulation of cation efflux in Nicotinic acetylcholine receptor alpha3-betaX subtype expressing IMR-32 cells; NT means not tested
Stimulation of cation efflux in Nicotinic acetylcholine receptor alpha3-betaX subtype expressing IMR-32 cells
Assay data:1 Active, 12 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Antagonistic activity against Nicotinic acetylcholine receptor (alpha3-betaX subunit) in IMR 32 cell line using 100 uM of (-)-nicotine as agonist
Antagonistic activity against neuronal nicotinic acetylcholine receptor (alpha3-betaX subunit) in IMR 32 cell line using 100 uM of (-)-nicotine as agonist
Assay data:26 Active, 4 Activity ≤ 1 µM, 27 Tested
siRNA Circadian Assay
Assay data:527 Active, 33364 Tested
SummaryPubMed CitationRelated BioAssays by Depositor
Agonist activity at human alpha6/alpha3beta2beta3 nAChR transfected in CHO cells assessed as calcium flux by FLIPR assay relative to control
Assay data:19 Tested
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