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Biological Data from US Patent US11891387: "Monoacylglycerol lipase modulators"
Assay data:105 Active, 1 Activity ≤ 1 nM, 85 Activity ≤ 1 µM, 108 Tested
SummaryRelated BioAssays by Target
[3H] 2-OG cleavage activity assay (PBMC)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
[3H] 2-OG cleavage activity assay (HeLa)
Inhibition of MGL activity in human HeLa cells assessed as reduction in cleaved [1,3-3H glycerol] level using [glycerol-1,3-3H]-oleoyl glycerol as substrate incubated for 1 hr
Assay data:6 Active, 6 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 6 Tested
Inhibition of human recombinant MAGL by fluorometric analysis
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Inhibition of human recombinant MAGL at 9.26 nM by fluorometric analysis
Assay data:4 Tested
Biological Assay from US Patent US11839663: "Radiolabelled MGL pet ligands"
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
MAGL Inhibitory Activity Assay from US Patent US11802133: "Heterocyclic compounds as monoacylglycerol lipase inhibitors"
Assay data:188 Active, 7 Activity ≤ 1 nM, 176 Activity ≤ 1 µM, 188 Tested
Biological Assay from US Patent US11802111: "Cyclobutyl amide monoacylglycerol lipase modulators"
Assay data:481 Active, 15 Activity ≤ 1 nM, 464 Activity ≤ 1 µM, 481 Tested
In Vitro Activity Assay from US Patent US11787798: "Aryl piperidines as monoacylglycerol lipase modulators"
Assay data:165 Active, 14 Activity ≤ 1 nM, 165 Activity ≤ 1 µM, 165 Tested
MAGL Enzyme Inhibition Assay from US Patent US11753371: "Disulfiram derivatives as ALDH1A1 and MAGL inhibitors"
Assay data:12 Active, 4 Activity ≤ 1 µM, 14 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Biological Assay from US Patent US11708359: "Monoacylglycerol lipase modulators"
Assay data:122 Active, 19 Activity ≤ 1 nM, 122 Activity ≤ 1 µM, 122 Tested
In Vitro Competitive Activity-Based Protein Profiling (Human) from US Patent US11691975: "MAGL inhibitors"
Assay data:25 Active, 5 Activity ≤ 1 µM, 25 Tested
In Vitro Competitive Activity-Based Protein Assay from US Patent US11655217: "Pyrazole MAGL inhibitors"
Assay data:252 Active, 249 Activity ≤ 1 µM, 252 Tested
Inhibition Assay from US Patent US11608347: "Octahydropyrido[1,2-alpha]pyrazines as MAGL inhibitors"
Assay data:91 Active, 1 Activity ≤ 1 nM, 64 Activity ≤ 1 µM, 93 Tested
In Vitro Activity Assay from US Patent US11597728: "Monoacylglycerol lipase modulators"
Assay data:426 Active, 29 Activity ≤ 1 nM, 414 Activity ≤ 1 µM, 427 Tested
In Vitro Activity Assay from US Patent US11512059: "Aminocyclobutanes as monoacylglycerol lipase modulators"
Assay data:50 Active, 14 Activity ≤ 1 nM, 50 Activity ≤ 1 µM, 50 Tested
Biological Assay from US Patent US11505546: "Azaspirocycles as monoacylglycerol lipase modulators"
Assay data:76 Active, 40 Activity ≤ 1 nM, 76 Activity ≤ 1 µM, 76 Tested
Inhibition of human recombinant MAGL in mouse brain membrane at 10 uM using TAMRA-FP serine hydrolase probe as substrate preincubated for 25 mins followed by substrate addition and measured after 25 mins SDS-PAGE analysis
Assay data:3 Active, 3 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Reversible inhibition of human recombinant MAGL using 4-nitrophenylacetate as substrate at 8 nM preincubated for 60 mins followed by 40X dilution with buffer and further incubated with substrate for 15 mins by microplate reader analysis
Assay data:1 Active, 1 Tested
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