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ChemBL affinity - Published Abbott papers from Article : "CHK1 in CSAR_FULL_RELEASE_3JULY2012"
Assay data:24 Active, 2 Activity ≤ 1 nM, 24 Activity ≤ 1 µM, 26 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of CHK1 in human MV4-11 cells assessed as reduction in autophosphorylation at S296 residue incubated for 2 hrs by Western blot analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human full length recombinant CHK1 assessed as residual activity at 10 uM using KKKVSRSGLYRSP as substrate incubated for 40 mins in presence of [gamma-33P]ATP at Km concentration by radiometric assay relative to control
Inhibition of CHK1 (unknown origin) at 1 uM relative to control
Assay data:2 Tested
Inhibition of hydroxyurea-induced CHK1 phosphorylation at S317 residue in human HCT116 cells at 20 uM treated for 8 hrs starting from 24 hrs post hydroxyurea addition by Western blot analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of CHEK1 (unknown origin) at 1 uM relative to control
Induction of CHK1/2 phosphorylation in human MDA-MB-231 cells assessed as increase in p53 phosphorylation at 10 uM after 6 to 24 hrs by Western blot method
Assay data:2 Active, 2 Tested
Inhibition of human CHK1 at 10 uM relative to control
Inhibition of His-tagged human CHK1 expressed in Escherichia coli at 10 uM
Assay data:9 Tested
Inhibition of CHK1 at 1 M
Inhibition of CHK1
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of CHK1 at 2 uM
Activity at human CHK1 in CA46 cells by histone H3 ELISA assay at 10 uM
Inhibition of CHK1 assessed as residual activity at 1 uM
Cell cycle arrest in H1299 cells assessed as accumulation at G2/M phase at 10 uM by FACS analysis
Inhibition of Chk1 at 10 uM ATP
Assay data:2 Active, 1 Activity ≤ 1 µM, 3 Tested
Inhibition of Serine/threonine-protein kinase Chk1 (CHK1) at 50 uM
Inhibition of Chk1 in presence of 10 uM ATP
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