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PLK4 Biochemical Assay from US Patent US20230365537: "POLO LIKE KINASE 4 INHIBITORS"
Assay data:271 Active, 30 Activity ≤ 1 nM, 268 Activity ≤ 1 µM, 271 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Selectivity interaction (KinomeScan (Ambit)) EUB0000687a PLK4
Assay data:1 Tested
SummaryRelated BioAssays by Target
Selectivity interaction (Kinase panel (ATP-site competition binding assay)) EUB0000122b PLK4
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Selectivity interaction (Enzymatic assay) EUB0000608a PLK4
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Thermal Shift Assay. Domain: start/stop: M1-M265
Assay data:27 Tested
Inhibition of PLK4 (unknown origin) at 0.1 uM relative to control
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of PLK4 (unknown origin) at 1.0 uM relative to control
Inhibition of PLK4 (unknown origin) at 1 uM relative to control
Inhibition of PLK4 (unknown origin) in the presence of ATP at Km concentration
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of PLK4 (unknown origin) at 2 uM relative to control
Inhibition of PLK4 (unknown origin) by Lanthascreen Eu Kinase binding assay
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of PLK4 (unknown origin)
Inhibition of PLK4 (unknown origin) at 0.5 uM relative to control
Inhibition of recombinant human PLK4 incubated for 60 mins by Lanthascreen Eu kinase binding assay
Assay data:43 Active, 8 Activity ≤ 1 nM, 41 Activity ≤ 1 µM, 43 Tested
PLK4 DiscoveRx kinase panel
PLK4 SGC Tm panel (DSF)
Plk4(h) Kinase panel
Inhibition of PLK4 (unknown origin) at 1 uM
Binding affinity to wild-type human partial length PLK4 (M1 to S273 residues) expressed in mammalian expression system assessed as residual binding level at 100 nM by Kinomescan method relative to control
Kinase Binding Assays from US Patent US10618912: "Diaryl macrocycles as modulators of protein kinases"
Assay data:18 Active, 13 Activity ≤ 1 nM, 17 Activity ≤ 1 µM, 18 Tested
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