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Displacement of tracer from recombinant Tb-labeled DNA polymerase theta (unknown origin) assessed as end point Kd using DNA as substrate preincubated for 30 mins followed by compound addition for 2 hrs by HTRF assay
Assay data:10 Active, 10 Activity ≤ 1 µM, 10 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human full length DNA polymerase theta ATPase activity by ADP-Glo assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Displacement of tracer from recombinant Tb-labeled DNA polymerase theta (unknown origin) assessed as Koff using DNA as substrate preincubated for 30 mins followed by compound addition for 2 hrs by HTRF assay
Assay data:4 Tested
Displacement of tracer from recombinant Tb-labeled DNA polymerase theta (unknown origin) assessed as Kon using DNA as substrate preincubated for 30 mins followed by compound addition for 2 hrs by HTRF assay
Displacement of tracer from recombinant Tb-labeled DNA polymerase theta (unknown origin) using DNA as substrate preincubated for 30 mins followed by compound addition for 2 hrs by HTRF assay
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Inhibition of recombinant human full length DNA polymerase theta using DNA substrate measured after 1 hrs in presence of dNTPs by plate reader assay
Assay data:39 Active, 33 Activity ≤ 1 µM, 41 Tested
Inhibition of human DNA polymerase theta assessed as substrate Km using dNTP as substrate at 40 nM
Inhibition of human DNA polymerase theta assessed as substrate Km using dNTP as substrate at 30 nM
Inhibition of human DNA polymerase theta assessed as substrate Km using dNTP as substrate at 20 nM
Inhibition of human DNA polymerase theta assessed as substrate Km using dNTP as substrate at 10 nM
Inhibition of human DNA polymerase theta assessed as substrate Km using dNTP as substrate at 5 nM
Inhibition of human DNA polymerase theta assessed as substrate Km using dNTP as substrate at 2.5 nM
Inhibition of human DNA polymerase theta assessed as substrate Vmax using dNTP as substrate at 40 nM
Inhibition of human DNA polymerase theta assessed as substrate Vmax using dNTP as substrate at 30 nM
Inhibition of human DNA polymerase theta assessed as substrate Vmax using dNTP as substrate at 20 nM
Inhibition of human DNA polymerase theta assessed as substrate Vmax using dNTP as substrate at 10 nM
Inhibition of human DNA polymerase theta assessed as substrate Vmax using dNTP as substrate at 5 nM
Inhibition of human DNA polymerase theta assessed as substrate Vmax using dNTP as substrate at 2.5 nM
Inhibition of human DNA polymerase theta using DNA 16/19 as substrate at 0.5 nM of enzyme concentration
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of human DNA polymerase theta using DNA 16/19 as substrate at 1 nM of enzyme concentration
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