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Inhibition of human thioredoxin signalling assessed as inhibition of insulin reduction at 50 uM
Assay data:3 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibitory concentration (25 uM) against human thioredoxin reductase
Assay data:1 Tested
Inhibitory concentration against wild type human thioredoxin reductase (5 nM) pre-incubated for 10 min at 25 degree C in buffer in the presence of 200 uM NADPH
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibitory concentration against wild type human thioredoxin reductase (30 nM) pre-incubated for 10 min at 25 degree C in phosphate buffer in the presence of 100 uM NADPH
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Inhibitory concentration against wild type mutant human thioredoxin reductase (hTrxRdelta-16) pre-incubated for 10 min at 25 degree C in buffer in the presence of 200 uM NADPH
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibitory concentration against wild type mutant human thioredoxin reductase (Sec498Cys) (100 nM) pre-incubated for 10 min at 25 degree C in buffer in the presence of 200 uM NADPH
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibitory concentration against wild type mutant human thioredoxin reductase (Sec498Cys) (1.3 uM) pre-incubated for 10 min at 25 degree C in buffer in the presence of 100 uM NADPH
Inhibitory concentration against wild type human thioredoxin reductase (30 nM) pre-incubated for 10 min at 25 degree C in phosphate buffer in the presence of 100 uM NADPH; Not determined
Inhibitory concentration against wild type mutant human thioredoxin reductase (Sec498Cys) (100 nM) pre-incubated for 10 min at 25 degree C in buffer in the presence of 200 uM NADPH; Not determined
Inhibitory concentration against wild type mutant human thioredoxin reductase (Sec498Cys) (1.3 uM) pre-incubated for 10 min at 25 degree C in buffer in the presence of 100 uM NADPH; Not determined
Inhibition of human TrxR
Assay data:2 Active, 11 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human thioredoxin signalling assessed as inhibition of insulin reduction at 10 uM
Inhibition of human thioredoxin signalling assessed as inhibition of insulin reduction at 25 uM
Inhibitory concentration against human thioredoxin reductase
Inhibition of human thioredoxin signalling assessed as inhibition of insulin reduction at 100 uM
Inhibition of human thioredoxin
Inhibition of human thioredoxin in MCF7 cell lysates by insulin assay
Effect on human thioredoxin redox state change in MCF7 cells assessed as decrease in 12-kDa monomer part at 2.5 uM after 48 hrs by Western blot
Assay data:1 Active, 1 Tested
Effect on human thioredoxin redox state change in MCF7 cells assessed as decrease in 12-kDa monomer part at 5.0 uM after 48 hrs by Western blot
Inhibition of TrxR in human HeLa cells at 50 uM after 12 hrs by insulin reduction assay
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