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MERTK SGC Tm panel (DSF)
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of MER (unknown origin) at 1 uM relative to control
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to recombinant MERTK (unknown origin) assessed as dissociation constant by DSF assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of recombinant MERTK (unknown origin) at 10 uM by DSF assay relative to staurosporine
Binding affinity to recombinant MERTK (unknown origin) assessed as change in melting temperature at 10 uM by DSF assay
MERTK, AXL, TYRO3 Kinase Homogeneous Time Resolved Fluorescence (HTRF) Assay from US Patent US20230339891: "URACIL DERIVATIVES AS MER-AXL INHIBITORS"
Assay data:128 Active, 13 Activity ≤ 1 nM, 128 Activity ≤ 1 µM, 128 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Human Mer Kinase Assay from US Patent US11708367: "Compounds for the treatment of kinase-dependent disorders"
Assay data:30 Active, 30 Activity ≤ 1 µM, 30 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Human Mer Kinase Assay from US Patent US11673897: "Compounds for the treatment of kinase-dependent disorders"
Assay data:11 Active, 11 Activity ≤ 1 µM, 11 Tested
TAM Enzymatic Assay from US Patent US11591338: "Pyrrolotriazine compounds as TAM inhibitors"
Assay data:142 Active, 144 Activity ≤ 1 µM, 144 Tested
Mer Kinase Assay from US Patent US11542259: "Compounds for the treatment of kinase-dependent disorders"
Assay data:64 Active, 65 Activity ≤ 1 µM, 65 Tested
Selectivity interaction (Enzymatic assay) EUB0000624a MERTK
Selectivity interaction (Upstate Kinase Profiler service (Millipore)) EUB0000056c MERTK
Affinity Biochemical interaction (HTRF assay) EUB0000147b MERTK
Affinity Phenotypic Cellular interaction (CellTiter-Glo assay (Promega, proliferation in H1703 cell line)) EUB0000147b MERTK
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Thermal Shift Assay. Domain: start/stop: E571-V864
Assay data:27 Tested
Inhibition of human wild type partial length Mer (R557 to L884 residues) expressed in bacterial expression system assessed as residual activity at 1 uM by Kinomescan method relative to control
Inhibition of human wild type partial length Mer (R557 to L884 residues) expressed in bacterial expression system by Kinomescan method
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